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SCIENCE BASE

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Science base

Disease models

Anterograde Tracing From the Göttingen Minipig Motor and Prefrontal Cortex Displays a Topographic Subthalamic and Striatal Axonal Termination Pattern Comparable to Previous Findings in Primates

Johannes Bech Steinmüller, Carsten Reidies Bjarkam, Dariusz
Orlowski, et al.
Nov 26, 2021

Doi: 10.3389/fncir.2021.716145

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Disease models

Plant Recombinant Human Collagen Type I Hydrogels for Corneal Regeneration

Haagdorens, M., Edin, E., Fagerholm, P, et al. Nov 1, 2021

Doi: 10.1007/s40883-021-00220-3

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Xenotransplantation

Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds

Sabrina Halecker, Julia Metzger, Christina Strube, et al. Nov 8, 2021

Doi: 10.3390/microorganisms9122617

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Devices, Disease models, Safety pharmacology

A 3-D Finite-Element Minipig Model to Assess Brain Biomechanical Responses to Blast Exposure

Aravind Sundaramurthy, Vivek Bhaskar Kote, Noah Pearson, et
al.
Nov 8, 2021

Doi: 10.3389/fbioe.2021.757755

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Devices

Low kV Computed Tomography of Parenchymal Abdominal Organs—A Systematic Animal Study of Different Contrast Media Injection Protocols

Daniel Overhoff, Gregor Jost, Michael McDermott et al. Jul 12, 2021

Doi: 10.3390/tomography7040069

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Disease models

A systematic review of porcine models in translational pain research

Suzan Meijs, Martin Schmelz, Sigal Meilin, and Winnie Jensen Nov 8, 2021

Doi: 10.1038/s41684-021-00862-4.

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Disease models

Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH

Laura Tvilling, Mark J. West, Andreas Glud, et al. Oct 4, 2021

Doi: 10.1007/s00429-021-02337-1

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In vitro pharmacology

The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs

Søren Østergaard, Johan F. Paulsson, Jacob Kofoed, et al. Oct 4, 2021

Doi: 10.1038/s41598-021-00654-3

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Disease models

Safety and efficacy of sFilm-FS, a novel biodegradable fibrin sealant, in Göttingen minipigs

Yuval Ramot, Michal Steiner, Yossi Lavie, et al. Oct 13, 2021

Doi: 10.1293/tox.2021-0030

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Disease models

Unraveling the Metabolic Derangements Occurring in Noninfarcted Areas of Pig Hearts With Chronic Heart Failure

Cláudia Correia, Qing-Dong Wang, Gunilla Linhardt, et al. Oct 13, 2021

Doi: 10.3389/fcvm.2021.753470

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Disease models, Safety pharmacology

[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction

Simon Bentsen, Andreas Clemmensen, Mathias Loft, et al. Aug 5, 2021

Doi: 10.3390/diagnostics11101807

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Disease models, Safety pharmacology

Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases

Allan Valenzuela, Claire Tardiveau, Miriam Ayuso, et al. Aug 5, 2021

Doi: 10.3390/13091442

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Guidelines

Anaesthesia & Analgesia Göttingen Minipigs

Adrian Zeltner Feb 8, 2022

Ellegaard Göttingen Minipigs can easily be anaesthetised for several hours without a higher risk of complications.

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Animal welfare

Taking Blood from Göttingen Minipigs while placed in a sling

Ellegaard Göttingen Minipigs A/S Nov 25, 2021

Minipigs, Iike any other animal. do not particularly like to be re­strained and being turned on their back with their belly exposed.

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Disease models

Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome

Rittase WB, McCart EA, Muir JM, et al. Aug 27, 2021

Doi: 10.1371/journal.pone.0256208

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Safety pharmacology, Toxicology

Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice

Namdari R, Jones K, Chuang SS, et al. Nov 15, 2021

Doi: 10.1016/j.yrtph.2021.105029

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Guidelines, Toxicology

Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig

Pardo ID, Manno RA, Capobianco R, et al. Aug 16, 2021

Doi: 10.1177/01926233211019941

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Disease models, Genetically altered models

In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer’s Disease

Andersen OM, Bøgh N, Landau AM, et al. Jul 13, 2021

Doi: 10.1101/2021.07.13.452149

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In vitro pharmacology, Toxicology

In Vitro and In Vivo Analysis of Ochratoxin A-Derived Glucuronides and Mercapturic Acids as Biomarkers of Exposure

Dekant R, Langer M, Lupp M, Chilaka CA, Mally A Aug 23, 2021

Doi: 10.3390/toxins13080587

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Disease models

Investigating the Multi-Faceted Nature of Radiation-Induced Coagulopathies in a Göttingen Minipig Model of Hematopoietic Acute Radiation Syndrome

Hritzo B, Legesse B, Ward JM, et al. Aug 16, 2021

Doi: 10.1667/RADE-20-00073.1.

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Disease models, In vitro pharmacology

Whole blood gene expression within days after total-body irradiation predicts long term survival in Gottingen minipigs

Chopra S, Moroni M, Sanjak J, et al. Aug 5, 2021

Doi: 10.1038/s41598-021-95120-5

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Disease models, In vitro pharmacology

Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH

Tvilling L, West M, Glud AN, et al. Sep 13, 2021

Doi: 10.1007/s00429-021-02337-1

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Disease models, Genetically altered models

The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues

Berthelsen MF, Riedel M, Cai H, et al. Jun 16, 2021

Doi: 10.3390/cancers13123024

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Disease models, Toxicology

Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration

Ding N, Yamamoto S, Chisaki I, Nakayama M, Matsumoto S, Hirabayashi H. Jun 9, 2021

Doi: 10.1016/j.dmpk.2021.100408

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Disease models

Preclinical Development and Validation of ASP5354: A Near-Infrared Fluorescent Agent for Intraoperative Ureter Visualization

Fushiki H, Yoshikawa T, Matsuda T, Sato T, Suwa A May 11, 2021

Doi: 10.1007/s11307-021-01613-0

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Disease models

Energy-Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and l-Menthol in Rat and Göttingen Minipig

Otake H, Yamaguchi M, Ogata F, et al. May 12, 2021

Doi: 10.3390/ijms22105137

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Disease models

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Brenner GB, Giricz Z, Garamvölgyi R, et al. Apr 17, 2021

Doi: 10.3791/61901

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Disease models

Obesity Development and Signs of Metabolic Abnormalities in Young Göttingen Minipigs Consuming Energy Dense Diets Varying in Carbohydrate Quality

Curtasu MV, Hedemann MS, Lærke HN, Knudsen KEB May 6, 2021

Doi: 10.3390/nu13051560

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Disease models, Toxicology

Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs

Lumley L, Du F, Marrero-Rosado B, et al. Apr 19, 2021

Doi: 10.1016/j.toxrep.2021.04.005

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Disease models

Hepatic blood flow in adult Göttingen minipigs and pre-pubertal Danish Landrace x Yorkshire pigs

Buyssens L, Clerck LD, Schelstraete W, et al. Aug 16, 2021

Doi: 10.1177/00236772211000370

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Disease models, In vitro pharmacology, Toxicology

Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling

Buyssens L, Clerck LD, Schelstraete W, et al. Apr 15, 2021

Doi: 10.3389/fphar.2021.665644

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Disease models, In vitro pharmacology

Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia

Armstrong AJ, Henke BR, Collado MS, et al. Apr 13, 2021

Doi: 10.1021/acs.jmedchem.1c00124

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Science base

Disease models

Göttingen Minipigs as a Model to Evaluate Longevity, Functionality, and Memory of Immune Response Induced by Pertussis Vaccines

Vaure C, Grégoire-Barou V, Courtois V, Chautard E, Dégletagne C, Liu Y Mar 17, 2021

Doi: 10.3389/fimmu.2021.613810

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Disease models, Genetically altered models

Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs

Maxeiner J, Sharma R, Amrhein C, et al. Mar 29, 2021

Doi: 10.1016/j.vascn.2021.106956

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Devices, Safety pharmacology

An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

Zaer H, Deshmukh A, Orlowski D, et al. Feb 3, 2021

Doi: 10.3389/fnhum.2021.618626

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models, Safety pharmacology

Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Hritzo B, Aghdam AY, Legesse B, et al. Mar 23, 2021

Doi: 10.3390/ijms22063286

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Science base

Genetically altered models

The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues

Berthelsen et al. Jun 16, 2021

Doi: 10.3390/cancers13123024

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Science base

Disease models, In vitro pharmacology, Safety pharmacology, Toxicology

The Porcine Immune System and the Toolbox Available to Study it

Ellegaard Göttingen Minipigs A/S Dec 16, 2019

The pig has a long-standing role in vaccine development and as model for human infectious diseases, and the immune system in the pig is well characterized.

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Safety pharmacology, Toxicology

The Gastrointestinal System and Oral PK in Göttingen Minipigs

Ellegaard Göttingen Minipigs A/S Dec 16, 2019

The pig is an omnivore and has a digestive physiology very similar to that in humans.

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Safety pharmacology, Toxicology

Göttingen Minipigs in ADME studies – specific advantages

Ellegaard Göttingen Minipigs A/S Dec 17, 2019

For several routes of administration, Göttingen Minipigs have specific advantages over other preclinical species in terms of predicting the drug absorption in humans…

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Safety pharmacology

Rapid One-Step Generation of Genetically Modified Göttingen Minipigs for Human Disease Modelling

Genome Biologics, Charles River Laboratories Copenhagen A/S, Ellegaard Göttingen Minipigs A/S Mar 2, 2020

For decades Göttingen Minipigs has been used in biomedical research, with their many anatomical, physiological and pathophysiological similarities to humans, and as…

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Disease models

Cardiometabolic Disease Models

Ellegaard Göttingen Minipigs A/S Dec 16, 2019

Göttingen Minipigs are very prone to obesity, and even chow feeding results in gross obesity if the minipigs are not kept on a restricted diet.

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Disease models

Göttingen Minipigs MR and CT Imaging Atlas

Ellegaard Göttingen Minipigs A/S May 11, 2020

A comprehensive imaging atlas presenting detailed information about the physiology of Göttingen Minipigs has been made available for anyone interested in the…

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Toxicology

The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations

Forster et al. Dec 1, 2010

Doi: 10.1016/j.vascn.2010.05.008

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Science base

Toxicology

The minipig as a platform for new technologies in toxicology

Forster et al. Dec 1, 2010

Doi: 10.1016/j.vascn.2010.05.007

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Science base

Guidelines

Genetic management of the Göttingen Minipig population

Simianer et al. Dec 1, 2010

Doi: 10.1016/j.vascn.2010.05.004

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Toxicology

The utility of the minipig as an animal model in regulatory toxicology

Bode et al. Dec 1, 2010

Doi: 10.1016/j.vascn.2010.05.009

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Devices, Safety pharmacology, Toxicology

Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products

Van der Laan et al. Dec 1, 2010

Doi: 10.1016/j.vascn.2010.05.005

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Animal welfare

Welfare of the minipig with special reference to use in regulatory toxicology studies

Ellegaard et al. Dec 1, 2010

Doi: 10.1016/j.vascn.2010.05.006

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Animal welfare, Toxicology

Ethical implications of using the minipig in regulatory toxicology studies

Webster et al. Dec 1, 2010

Doi: 10.1016/j.vascn.2010.05.002

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Toxicology

The RETHINK project: Minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment

Forster et al. Dec 1, 2010

Doi: 10.1016/j.vascn.2010.05.003

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Science base

Guidelines

Histology of Göttingen Minipigs

Roger Burnett Aug 1, 2019

These notes have been produced to accompany the double DVD set on Göttingen Minipigs histology. 

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Guidelines

Management of Pregnant Göttingen Minipigs and Their Litter

Adrian Zeltner Aug 1, 2019

When planning a juvenile study with dosing start as early as PND1 onwards, you will need to have pregnant sows delivered to your facility.

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Science base

Guidelines

Catheters and Vascular Access Ports (VAP) in Göttingen Minipigs

Adrian Zeltner Aug 1, 2019

The main reason for using catheters in a minipig is to facilitate repeated serial blood sampling or intravenous dosing.

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Guidelines

Handling, Dosing and Training of Göttingen Minipigs

Adrian Zeltner Aug 1, 2019

When working with any type of animal, a profound understanding of the involved species is paramount.

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Guidelines

Acclimatization, socialization, and welfare of Göttingen Minipigs

Adrian Zeltner Aug 1, 2019

This document focuses on the time immediately after the minipig has been transported to your facility until the beginning of the experimental procedures.