Juvenile and neonatal studies
Göttingen Minipigs provide a scientifically robust model for juvenile and neonatal studies, supporting the assessment of age-dependent pharmacokinetics, safety, and development. Their postnatal growth and organ maturation patterns more closely parallel those of humans than those of rodents, enabling meaningful evaluation of pediatric medicines and early-life exposures. Göttingen Minipigs offer a defined developmental timeline and fewer species-specific sensitivities, while their manageable size facilitates repeated sampling and longitudinal follow-up from the neonatal to the adult stage. Well-characterised reference data on hepatic enzyme ontogeny, immune maturation, and physiological development further strengthen their relevance. These qualities make Göttingen Minipigs particularly valuable for studying juvenile pharmacology and toxicology, bridging the gap between preclinical and pediatric clinical research.
Lenz JH, Henkel KO, Schmidt W, et al.
Ossification of the frontal sinus in juvenile minipigs following water jet application
Journal of Cranio-Maxillo-Facial Surgery
Published: Mar 2006
DOI: 10.1016/j.jcms.2005.09.002
Haagensen AMJ, Grand N, Klastrup S, et al.
Spatial discrimination and visual discrimination: two methods evaluating learning and memory in juvenile Göttingen minipigs
Behavioural Pharmacology
Published: Jun 2013
DOI: 10.1097/FBP.0b013e32836104fd
Lorenzen E, Kudirkiene E, Gutman N, et al.
The vaginal microbiome is stable in prepubertal and sexually mature Ellegaard Göttingen Minipigs throughout an estrous cycle
Veterinary Research
Published: Oct 2015
DOI: 10.1186/s13567-015-0274-0
Peer EV, Downes N, Casteleyn C, et al.
Organ data from the developing Göttingen minipig: first steps towards a juvenile PBPK model
Journal of Pharmacokinetics and Pharmacodynamics
Published: Apr 2016
DOI: 10.1007/s10928-015-9463-8
Feyen B, Penard L, Heerden MV, et al.
"All pigs are equal" Does the background data from juvenile Göttingen minipigs support this?
Reproductive Toxicology
Published: Sep 2016
DOI: 10.1016/j.reprotox.2016.04.019
Peer EV, Jacobs F, Snoeys J, et al.
In vitro Phase I- and Phase II-Drug Metabolism in The Liver of Juvenile and Adult Göttingen Minipigs
Pharmaceutical Research
Published: Apr 2017
DOI: 10.1007/s11095-017-2101-y
Siefert J, Hillebrandt KH, Kluge M, et al.
Computed tomography-based survey of the vascular anatomy of the juvenile Göttingen minipig
Laboratory Animals
Published: Aug 2017
DOI: 10.1177/0023677216680238
Gauthier BE, Penard L, Bordier NF, et al.
Specificities of the Skin Morphology in Juvenile Minipigs
Toxicologic Pathology
Published: Oct 2018
DOI: 10.1177/0192623318804520
Siefert J, Hillebrandt KH, Moosburner S, et al.
Hepatocyte Transplantation to the Liver via the Splenic Artery in a Juvenile Large Animal Model
Cell Transplantation
Published: Dec 2019
DOI: 10.1177/0963689719885091
Smits A, Annaert P, Cruchten SV, Allegaert K
A Physiology-Based Pharmacokinetic Framework to Support Drug Development and Dose Precision During Therapeutic Hypothermia in Neonates
Frontiers in Pharmacology
Published: May 2020
DOI: 10.3389/fphar.2020.00587
Vrolyk V, Desmarais MJ, Lambert D, et al.
Neonatal and Juvenile Ocular Development in Göttingen Minipigs and Domestic Pigs: A Histomorphological and Immunohistochemical Study
Veterinary Pathology
Published: Nov 2020
DOI: 10.1177/0300985820954551
Curtasu MV, Tafintseva V, Bendiks ZA, et al.
Obesity-Related Metabolome and Gut Microbiota Profiles of Juvenile Göttingen Minipigs—Long-Term Intake of Fructose and Resistant Starch
Metabolites
Published: Nov 2020
DOI: 10.3390/metabo10110456
Allais L, Brisebard E, Ravas N, et al.
Skin immune cell characterization in juvenile and adult Göttingen Minipigs
Regulatory Toxicology and Pharmacology
Published: Mar 2021
DOI: 10.1016/j.yrtph.2021.104861
Valenzuela A, Tardiveau C, Ayuso M, et al.
Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases
Pharmaceutics
Published: Sep 2021
DOI: 10.3390/pharmaceutics13091442
Allais L, Perbet A, Condevaux F, et al.
Immunosafety evaluation in Juvenile Göttingen Minipigs
Journal of Immunotoxicology
Published: Dec 2022
DOI: 10.1080/1547691X.2022.2088904
Stroe MS, Bockstal LV, Valenzuela A, et al.
Development of a neonatal Göttingen Minipig model for dose precision in perinatal asphyxia: technical opportunities, challenges, and potential further steps
Frontiers in Pediatrics
Published: May 2023
DOI: 10.3389/fped.2023.1163100
Leys K, Stroe MS, Annaert P, et al.
Pharmacokinetics during therapeutic hypothermia in neonates: from pathophysiology to translational knowledge and physiologically-based pharmacokinetic (PBPK) modeling
Expert Opinion on Drug Metabolism & Toxicology
Published: Jul-Dec 2023
DOI: 10.1080/17425255.2023.2237412
Sun J, Chong J, Zhang J, Ge L
Preterm pigs for preterm birth research: reasonably feasible
Frontiers in Physiology
Published: Jul 2023
DOI: 10.3389/fphys.2023.1189422
