Microbiological standardisation is necessary because of the possible interference of pathogens with experimental results. Known effects of microorganisms on animal experiments are pathological changes, immunomodulation, physiological changes, interference with reproduction, competition of pathogens within the animal, oncogenesis and contamination of biological products. The influence of these factors can be reduced by using microbiologically defined animals for experiments.
We keep the population of microbiologically defined minipigs in two full barrier facilities which include HEPA-filtered ventilation with 100% fresh air, overpressure, disinfection locks for diet and materials, shower locks for personnel and a closed manure system.
Like all other procedures within the company, the high standard of health is regulated by the SOPs (Standard Operating Procedures). Every staff member is instructed in the use and importance of the SOPs.
Due to the caesarian rederivation in 1992 and the strict barrier conditions since then, the microbiological status in the colonies is controlled and clinical disease is very rare.
Based on FELASA recommendations, the colonies are health monitored twice a year and tested for a wide range of pathogens. The latest results, incl. historical results are published in the Health Monitoring Report (HMR).
The colony is screened for selected agents in May/June and an extended analysis is performed in November/December.
The tests for Influenza H1N1, Lawsonia intracellularis, Salmonella and Yersinia enterocolitica are done on pooled samples based on recommendations from the Danish Technological University. The amount of sampling material is identical to individual sampling.
HMR for all Barriers - December 2019
Please send an email to our Veterinarian if you have any questions regarding the health and welfare of Göttingen Minipigs.
Previous Health Monitoring Report information: