Microbiological standardisation is necessary because of the possible interference of pathogens with experimental results. Known effects of microorganisms on animal experiments are pathological changes, immunomodulation, physiological changes, interference with reproduction, competition of pathogens within the animal, oncogenesis and contamination of biological products. The influence of these factors can be reduced by using microbiologically defined animals for experiments.
We keep the population of microbiologically defined minipigs in two full barrier facilities which include HEPA-filtered ventilation with 100% fresh air, overpressure, disinfection locks for diet and materials, shower locks for personnel and a closed manure system.
Like all other procedures within the company, the high standard of health is regulated by the SOPs (Standard Operating Procedures). Every staff member is instructed in the use and importance of the SOPs.
Due to the caesarian rederivation in 1992 and the strict barrier conditions since then, the microbiological status in the colonies is controlled and clinical disease is very rare.
Based on FELASA recommendations, the colonies are health monitored twice a year and tested for a wide range of pathogens. The latest results, incl. past results are published in the Health Monitoring Report (HMR).
The colony is screened for selected agents in May/June and an extended analysis is performed in November/December.
There has been no changes in the overall health status.
New Health Monitoring Reports:
The biannual Health Monitoring Report (HMR) from Ellegaard Göttingen Minipigs has been updated, as our HMR is based on the newest Federation of European Laboratory Animal Science Associations (FELASA) guidelines. In August 2020, FELASA published their new guidelines “Federation of European Laboratory Animal Science Associations recommendations of best practices for the health management of ruminants and pigs used for scientific and educational purposes”. Some highlights in the new HMR:
If you have any questions regarding the changes to the HMR, or the health and welfare of Göttingen Minipigs, please send an email to our attending Veterinarian.
Previous Health Monitoring Reports:
Health Monitoring Information June 2020
Health Monitoring Information December 2019
Health Monitoring Information June 2019
Health Monitoring Information December 2018
Health Monitoring Information June 2018
Health Monitoring Information January 2018
Health Monitoring Information July 2017
Health Monitoring Information December 2016
Health Monitoring Information July 2016
Health Monitoring Information December 2015
Health Monitoring Information May 2015
Health Monitoring Information October 2014
Health Monitoring Information April 2014
Health Monitoring Information August 2013
Health Monitoring Information May 2013
Health Monitoring Information April 2013