Microbiological standardisation is necessary because of the possible interference of pathogens with experimental results. Known effects of microorganisms on animal experiments are pathological changes, immunomodulation, physiological changes, interference with reproduction, competition of pathogens within the animal, oncogenesis and contamination of biological products. The influence of these factors can be reduced by using microbiologically defined animals for experiments.
We keep the population of microbiologically defined minipigs in two full barrier facilities which include HEPA-filtered ventilation with 100% fresh air, overpressure, disinfection locks for diet and materials, shower locks for personnel and a closed manure system.
Like all other procedures within the company, the high standard of health is regulated by the SOPs (Standard Operating Procedures). Every staff member is instructed in the use and importance of the SOPs.
Due to the caesarian rederivation in 1992 and the strict barrier conditions since then, the microbiological status in the colonies is controlled and clinical disease is very rare.
Based on FELASA recommendations, the colonies are health monitored twice a year and tested for a wide range of pathogens. The latest results, incl. historical results are published in the Health Monitoring Report (HMR).
The colony is screened for selected agents in May/June and an extended analysis is performed in November/December.
All samples were analyzed by Statens Serum Institute (SSI), Denmark. Since January 2020 SSI has included veterinary diagnostic to their areas of expertise and is accredited as National Reference Laboratory as part of a national One-Health strategy. All analyses were performed with compliance to current requirements and guidelines.
Important note: A few tests have been replaced by other test methods as per recommendation by SSI. No samples were pooled. Overall, there are no changes to the health status of Göttingen Minipigs in any of our barriers. As SSI has been extensively involved with diagnostic, research and surveillance of Covid-19, it has not been possible to perform all the tests which are usually included in our biannual health monitoring. However, all analyses will be performed with the health monitoring at the end of 2020.
Please send an email to our Veterinarian if you have any questions regarding the health and welfare of Göttingen Minipigs.
Previous Health Monitoring Reports:
Health Monitoring Information December 2019
Health Monitoring Information June 2019
Health Monitoring Information December 2018
Health Monitoring Information June 2018
Health Monitoring Information January 2018
Health Monitoring Information July 2017
Health Monitoring Information December 2016
Health Monitoring Information July 2016
Health Monitoring Information December 2015
Health Monitoring Information May 2015
Health Monitoring Information October 2014
Health Monitoring Information April 2014
Health Monitoring Information August 2013
Health Monitoring Information May 2013
Health Monitoring Information April 2013