By Philip Hove Ravn
As a part of a school initiative I spent a week as an intern at Ellegaard Göttingen Minipigs (EGM). During my week I was introduced to EGM’s services and what a work day looks like in the company supplying the pharmaceutical industry with Göttingen Minipigs for biomedical research. I have always had an interest in science, especially biology and things related to humans, animals and nature. One of the goals for the internship is to try out something which you might want to work with as an adult. Since I want to work in the pharmaceutical industry, EGM was a really great place to experience a special part of that industry.
My internship lasted four days, and every day I learned new things and acquired new skills. I started the week off being together with the staff inside one of the breeding barriers. I got a tour of the facility and was given a brief explanation of the work processes inside a minipig barrier. Before entering the barriers, I was guided through the standard operation procedure for barrier admission which included showering and changing clothes. Inside the barrier I got my first look at the minipigs: It was somewhat as I expected, but I think that few things can really prepare you for the smell inside a minipig barrier! This is something you must get used to. I live in the city and has never really been around that many farm animals before, so everything was new and exciting to me. After my first brief tour of the facility, I was set to work and spent my day socialising with the minipigs, and of course cleaning and feeding which is quite hard work: you easily break a sweat!
On the second day I got to see how blood samples are taken, as well as how a veterinarian's day looks like; I joined the EGM veterinarian who attended to animals that needed care, for instance because of a wound from biting or an irritated eye. I was surprised to see how few animals actually needed the veterinarian’s attendance. During our rounds, I was also explained about initiatives to improve the animal welfare which is a very high priority at EGM as well as a great attention to detail and the wish only to provide the highest quality which really made an impression on me.
Wednesday was split up into two: I was inside one of the breeding barriers until lunchtime, and I spent the afternoon at the administration building, partly with the employees of the research barrier in a meeting where they discussed input from customers. It was nice to see how the staff shared knowledge and talked about challenges, improvements and solutions. The rest of the afternoon I spent at the office where I got a quick view of the routines and tasks connected to the administration of the company. I also participated in an interesting introduction for new employees on the scientific background and use of Göttingen Minipigs.
My last day was spent inside the research barrier where I attended surgery and later autopsy of a minipig performed by the EGM laboratory technician. It was a very interesting day to me filled with new experiences and I really learned a lot. Altogether, my internship at EGM was very educational, and I had many new experiences and got to see almost every aspect of the company. I met very interesting people who are dedicated to their different jobs, and that really contributed to my overall experience. My impression of Ellegaard Göttingen Minipigs is that it is a company with high attention to detail and generally also high standards with employees that are very service-minded and focused on keeping their customers satisfied. I'm very glad that I got to meet so many different and nice people and my internship created a lot of good memories.
We are very pleased to announce that the Scientific Board of Ellegaard Göttingen Minipigs Research Foundation has granted 35,000 Euro to the project “Speedgene targeted knock out of the PCSK-9 gene in Göttingen Minipigs” and the research teams behind the project, led by Dr. Jaya Krishnan and Dr. Jonathan Ward, Genome Biologics, together with Dr. Roy Forster, Citoxlab.
The grant was announced last week by CEO Lars Friis Mikkelsen during the 12th Minipig Research Forum in Barcelona. Director of Toxicology of Citoxlab France, Pramila Singh, was honoured to receive the diploma from Lars Friis Mikkelsen on behalf of the winning project team.
For further information regarding the MRF 2018 registration, meeting details, preliminary programme, venue and accommodation, please contact us at email@example.com or visit www.minipigresearchforum.org
We look forward to seeing you in Barcelona!
To all of you, Happy Holidays and Best Wishes!
Minipig Research Forum Steering Committee
Our Laboratory Animal Veterinarian, Kirsten Rosenmay Jacobsen and CEO, Lars Friis Mikkelsen are attending the AALAS Annual National Meeting in Austin, Texas, 15-19 October 2017. On Wednesday, 18 October 2017 from 2:45 to 5:00 PM, we are together with Marshall BioResources, organizing an Exhibitor Hosted Session:
Tools for Developing a Stimulating and Cooperative Environment for Laboratory Minipigs
2:45 PM - 5:00 PM/Room: 18B
Leader: Nicole Navratil
Moderator: Kirsten R. Jacobsen, Michelle L. Salerno
Facilitator: Pam Huber
The complexity of swine cognition should not be underestimated in the laboratory. When developing behavioral management and husbandry procedures for laboratory minipigs, it is important to remember that minipigs are highly intelligent with a unique perspective about their environment. This intelligence can cause a challenge to providing stimulating environments, but it can also provide a benefit as minipigs can be trained to participate in study procedures. This seminar will review ways in which minipigs may experience their environment, how to evaluate and mitigate stress, as well as ways to help enhance environmental stimulation. This seminar is valuable for technicians, veterinarians, and managers who work directly with minipigs in their laboratory facilities.
|2:45||Nicole Navratil||Welcome and introductions|
|2:50||Kirsten R. Jacobsen||Introduction to swine behavioral management|
|3:15||Carolyn M. Allen||Providing cognitively stimulating enrichment for laboratory swine|
|3:40||Felipe Berard||Evaluation of stress and acclimation to new environments, procedures or equipment|
|4:05||Michelle L. Salerno||Mutual cooperation and training minipigs for blood collection and other procedures|
This Seminar is sponsored in part by Marshall BioResources and Ellegaard Gottingen Minipigs.
We look forward to seeing you in Austin!
Ellegaard Göttingen Minipigs looks forward to seeing you at the Safety Pharmacology Society (SPS) Annual Meeting 24-27 September 2017 in Berlin. We invite you to visit our booth #207 and meet our CEO, Lars Friis Mikkelsen and CSO, Henrik Duelund Pedersen to discuss the use of Göttingen Minipigs in safety assessment.
You can contact us directly at firstname.lastname@example.org to arrange an appointment for a meeting. We look forward to seeing you in Berlin!
Visit us at EUROTOX in Bratislava 10th to 13th of September where we on Tuesday the 12th at 14:00-15:00 host the exhibitor session "The Göttingen Minipig as a preferred toxicology species". The session will focus on the importance of optimized and scientifically based species selection in toxicology and safety studies, in which the importance of considering the Göttingen Minipig will be presented. Furthermore, the opportunity of developing and using transgenic Göttingen Minipigs as an animal model in pharmacological studies and the impact on species selection in toxicology and safety studies will be discussed in this session.
Further, visit us in booth no. 27/28.
This paper compares results from safety assessment of four single-stranded oligonucleotide drugs in Göttingen Minipigs and non-human primates (NHPs). The minipig shows a similar safety profile as the NHP, and the authors conclude that the data support the use of Göttingen Minipigs as non-rodent species in the preclinical safety assessment of this class of molecules.
Read more about this interesting study in the article: Braendli-Baiocco A, et al. “The Minipig is a Suitable Non-Rodent Model in the Safety Assessment of Single Stranded Oligonucleotides” Toxicological Sciences 2017 Jan 25 [Epub ahead of print]
Henrik Duelund Pedersen started as Head of Scientific Management at Ellegaard Göttingen Minipigs on 1 February 2017. He is responsible for providing scientific support to customers and will represent the company in scientific collaborations. Henrik is also in charge of implementing our ambition to further develop and characterise Göttingen Minipig-based models through in-house activities and scientific collaborations.
Henrik received his DVM degree in 1992 and he was PhD-student, Assistant Professor and Associate Professor at Copenhagen University for the first 12 years. Then, in 2000, Henrik became Doctor of Veterinary Science and has maintained a close association with the university, where he now serves as Affiliated Professor of Veterinary Pharmacology. Since 2004, Henrik has been involved in vivo pharmacology in the pharmaceutical and biotech industries, both as scientist and manager. In 2009, Henrik received a MSc (Industrial Drug Development). Henrik has extensive experience in developing and optimising in vivo platforms and models – often in collaboration with partners from universities and private companies. His expertise in this context is non-rodent species, especially pigs and minipigs.
Henrik lives in Lyngby, near Copenhagen, with his wife. Their two children, a daughter and a son, recently moved into their own flats in Copenhagen. Henrik enjoys spending time with family and friends in his spare time, and he enjoys various outdoor activities, gardening, cutting wood with his chainsaw, playing bridge and making his own snaps.
We hope that you will soon have an opportunity to meet Henrik and discuss your work with Göttingen Minipigs. You are welcome to contact him if you have any questions or challenges regarding the use of Göttingen Minipigs in biomedical research.
Clinical chemistry and hematology reference data for juvenile Göttingen Minipigs aged 2 days as well as 1, 2, 4 and 5 weeks is now available. Please visit our webpage: background data or contact Adrian Zeltner, Customer Support & Veterinary Services, if you have any questions.
Here you can also find a poster about: "Reference data of clinical chemistry and hematology in juvenile Göttingen Minipigs".
Based on FELASA recommendations, our colonies are health monitored twice a year and tested for a wide range of pathogens. The latest results, including historical data, are published in the Health Monitoring Report (HMR) for Barrier II and III, and you can find the link to the report here.
Please feel free to contact Kirsten Rosenmay Jacobsen, Laboratory Animal Veterinarian, if you have any questions regarding the health and welfare of Ellegaard Göttingen Minipigs.
It is a great pleasure for us to invite you to the RTC – Ellegaard joint round table meeting on 9th of February in Frankfurt, Germany, entitled: “The Göttingen Minipig in Regulatory Toxicology".
The main objective of this Round Table is to discuss the latest developments in the use of swine in biomedical and translational research with an emphasis on non clinical safety testing in the Göttingen Minipig. The full day lectures, presented by experts with long and recognized experience in preclinical studies, will deal with the assessment of the current status of use of Göttingen Minipigs in toxicology studies, as well as with the potential future strategies for the use of the Göttingen Minipig as non-rodent animal model in toxicology.
Please contact us for further information about the round table meeting.
We look forwad to meeting you in Germany!
The 11th MRF meeting will take place in Cambridge, UK, on 17-19 May 2017.
The topics for the meeting will be:
There will also be workshops and time for networking with other Minipig users. The program will be announced at a later date. If you wish to give a presentation on any of the topics, or if you have related posters, please contact MRF.
Prior to the actual start of the MRF meeting we would like to invite you to a get-together evening on Wednesday 17 May 2017, which will be an evening buffet with food and drinks from 6-10 pm. We do hope to see as many of you as possible, so please keep this in mind when booking your flights. The get-together evening will be at the same hotel as the venue, which makes it convenient for check-in, leaving your luggage and joining us in the evening.
For further details about the meeting and registration, please visit the MRF´s new website.
We look forward to seeing you in Cambridge!
To all of you, Happy Holidays and Best Wishes!
Minipig Research Forum Steering Committee
Adrian Zeltner, Customer Support & Veterinary Services, will present the poster: "VAP placement for saphenous vein catheters in Göttingen Minipigs" at the Laboratory Animal Science Associations (LASA) Annual Conference on 22-24 November 2016 in South of England.
You are welcome to contact Adrian directly for further information.
Our veterinarian Kirsten Rosenmay Jacobsen will be attending the ESLAV-ECLAM 2016 Annual Scientific Meeting on 15-18 November 2016 in Lyon, France, where Kirsten will present the poster: “Modified ice block as an alternative type of occupational enrichment for adult Göttingen Minipigs”. You are welcome to contact Kirsten directly to arrange an appointment for a meeting.
We look forward to seeing you in Lyon!
Our CEO Lars Friis Mikkelsen will be attending the 7th Asian Federation of Laboratory Animal Science Associations (AFLAS) Congress on 7-11 November 2016 in Singapore, where Lars will give a presentation about the: “Optimized housing and care of Göttingen Minipigs”.
You are welcome to contact Lars directly to arrange an appointment for a meeting during the congress.
We look forward to seeing you in Singapore!
Jens Ellegaard has managed to create a successful niche business and has received the well-deserved PwC “Family Business Award 2016” in the Zealand region, Denmark.
We are very pleased to announce that the Scientific Board of Ellegaard Göttingen Minipigs Research Foundation has granted a total of EUR 100,000.00 to Prof. Dr. Steven Van Cruchten and his research team from the University of Antwerp to support the project: “Construction and activity of recombinant cytochrome P450 enzymes as an in vitro system for reaction‐phenotyping of drug candidates in the Göttingen Minipig”.
This article presents background data from 82 piglets collected at different ages. The data described show the normal variations and changes which are important in the interpretations of juvenile studies. In the article age-related changes are reported for several cardiac and clinical pathology parameters and in the haematopoietic tissues.
Read more about this exciting study in the article: Feyen B. et al. "All pigs are equal" Does the background data from juvenile Göttingen minipigs support this? Reproductive Toxicology 64 (2016) 105-115.
Many human diseases with a genetic etiology have dominantly been replicated in rodent models or genetically modiﬁed mice models. But for some diseases, translation to the clinic has failed as rodent models did not faithfully recapitulate key aspects of the disease phenotype.
Read more about why the Göttingen Minipigs should be considered as an attractive animal model for Alzheimer´s Disease in Jakobsen JE et al. "Expression of the Alzheimer’s Disease Mutations AβPP695sw and PSEN1M146I in Double-Transgenic Göttingen Minipigs" Journal of Alzheimer’s Disease 53 (2016) 1617–1630.
Ellegaard would be very pleased to meet you during the 42nd AFSTAL annual congress on 12-14 October 2016 in Nantes, France.
We invite you to visit our booth # 83 and take the opportunity to meet our team: Jens Ellegaard and Peter Vestbjerg, and discuss the latest developments and how you can work with Göttingen Minipigs. You are welcome to contact Jens or Peter directly to arrange an appointment for a meeting.
We look forward to welcoming you in Nantes!
Our CEO Lars Friis Mikkelsen will be attending the 12th Scientific Conference of Chinese Association for Laboratory Animal Sciences (CALAS) on 9-11 October 2016 in Nanning, China, where Lars will give a presentation about the: “Göttingen Minipig in scientific research”. You are welcome to contact Lars directly: email@example.com to arrange an appointment for a meeting.
We look forward to seeing you in Nanning!
Our CEO Lars Friis Mikkelsen will be attending the Safety Pharmacology Society, 16th Annual Meeting on 18-21 September 2016 in Vancouver, Canada. You can meet Lars at Marshall BioResources´ booth #415 during the meeting or contact him directly firstname.lastname@example.org to arrange an appointment for a meeting.
Here you can find more information about the meeting.
We look forward to seeing you in Vancouver!
11–14th September 2016 in Dublin, Ireland
Ellegaard will attend the 44th annual meeting of the European Teratology Society in Dublin, Ireland. We at Ellegaard are glad to support this year meeting and hope to see you there.
In collaboration with CiToxLAB Scantox A/S, Denmark and Charles River Laboratories, in France and the Netherlands we will present a poster entitled: “The incidence of external and visceral congenital malformations and variations in Göttingen Minipigs”.
Here you can find more information about the meeting.
We look forward to seeing you in Dublin!
Our team would be very pleased to meet you during the 52nd European Congress of the European Societies of the Toxicology. The theme of this year’s EUROTOX congress is: “Protecting Public and Environmental Health by Understanding and Communicating Toxicology”.
We invite you to visit our booth and take the opportunity to meet our team: Anette Blak Grossi, Peter Vestbjerg, Jens Ellegaard and Lars Friis Mikkelsen and discuss the latest developments and how you can work with Göttingen Minipigs.
You are also invited to take a look at our presented poster by Anette Blak Grossi: “Reference data of clinical chemistry and hematology in juvenile Göttingen Minipigs”.
We look forward to welcoming you in Seville!
Kirsten Rosenmay Jacobsen started at Ellegaard Göttingen Minipigs as Laboratory Animal Veterinarian on 1 August 2016.
Kirsten graduated as veterinarian in 2009, specialized in biomedicine. In 2012 she received her PhD from the Department of Experimental Medicine, University of Copenhagen, working on refined analgesic treatment and pain assessment of laboratory mice. Concurrent with her PhD studies, Kirsten received training in non-human primate behaviour, enrichment and welfare at the Michale E. Keeling Center for Comparative Medicine and Research in Texas. In 2013, Kirsten joined the In Vivo Pharmacology group at Translational Medicine Research Centre, MSD in Singapore, before being hired by Scanbur as Scientific Affairs Manager in 2015.
Kirsten has a strong scientific background in the field of animal welfare and looks forward to providing veterinary support and guidance to our customers, as well as keeping Göttingen Minipigs at a high standard in terms of both health and welfare. Together with Anette Blak Grossi, Head of Scientific Management, she will provide scientific support to internal and external projects and collaborations.
Kirsten lives in Menstrup with her husband and daughter. She spends most of her spare time with the family, working on their small farm or travelling abroad.
We hope that you will have the opportunity to meet Kirsten and discuss your work with Minipigs. You are welcome to contact her if you have any veterinary questions or challenges regarding the use of our Minipigs.
The next MRF meeting will start with welcome reception/get-together evening on 17th of May and end on 19th of May mid-afternoon. The MRF meeting will take place in Cambridge, England. Mark your calendar for the 2017 MRF Meeting!
Further details will be made available soon on the MRF website: www.minipigresearchforum.org and MRF LinkedIn.
Peter Vestbjerg started as Head of Business Development for Ellegaard Göttingen Minipigs in July 2016.
Peter will be responsible for supporting and overseeing the implementation of our sales strategy. This includes identifying new and develop existing customers and scientific partners, in close collaboration with our Scientific Management, as well as expanding our scientific services by identifying market trends and customer needs and establishing future product and service strategies.
Peter has been working with sales and exports for the last 20 years and has a graduate degree in international business from Copenhagen Business School. For the past 13 years, Peter has been responsible for selling full solutions for Scanbur, which supplies full solutions to animal research facilities.
Peter lives near Køge – halfway between Ellegaard and Copenhagen, with his wife and two daughters. Peter enjoys travelling and likes to cook for family and friends in his spare time.
1st of June 2016, Lena Toft started at Ellegaard Göttingen Minipigs as Management Assistant.
Lena has an BSc in English and German from Copenhagen Business School and has an academy degree in marketing from Copenhagen Business Academy.
Lena has wide experience in international business and comes from a position as purchase coordinator with Netto, Denmark’s largest retail chain store, where she was responsible for the purchase of books and kids’ stationary and worked as coordinator for a group of product managers within the international nonfood department.
At Ellegaard Lena will mainly assist CEO Lars Friis Mikkelsen and the management team. She will be responsible for supporting the cooperation with external business partners, follow-up on agreements and contracts covering internal and external scientific projects, planning of meetings, follow-up on actions and several other administrative assignments.
Lena lives in Køge – half way between Dalmose and Copenhagen – with her husband and two teenage sons. Most of her spare time is spent with the family either at home or travelling abroad.
Lena is devoted to her work and looks forward to supporting and guiding you in any administrative matter. You are welcome to contact her.
A Göttingen Minipig has been on an important mission with a team of medical doctors and researcher from Aalborg University Hospital and the Royal Danish Air Force. The anaesthetized Göttingen Minipig was used to successfully test a new method of applying pure oxygen to the lungs of a non-breathing person, which will help airborne transport of severely lung-injured people like wounded soldiers or civilians after bomb attacks.
Please see more in Danish here.
Our team would be very pleased to meet you during the FELASA 2016 Congress.
We invite you to visit our booth and take the opportunity to meet our team: Ann-Sofie Søndergaard, Adrian Zeltner, Jens Ellegaard and Lars Friis Mikkelsen and discuss the latest developments and how you can work with Göttingen Minipigs.
You are also invited to take a look at our presented posters: “Modified ice block as an alternative type of occupational enrichment for adult Göttingen Minipigs” and “Vascular access port placement for saphenous vein catheters in Göttingen Minipigs”.
We look forward to welcoming you in Brussels!
Special Issue: Swine in Translational Research and Drug Development
The newly published special issue of Toxicologic Pathology, Volume 44, Number 3, 2016, addresses the latest developments in the utilization of swine in biomedical and translational research with an emphasis on toxicological pathology and nonclinical safety testing in the Minipig. It provides an assessment of the current status of swine in research and the increasing use of the Minipig in toxicology studies, as well as potential future strategies for the use of the Minipig as a replacement for other non-rodent animal models.
Adrian Zeltner has contributed to the article: "Sexual Maturation in the Female Göttingen Minipig" and Anette Blak Grossi has contributed to the article: "Vehicle Systems and Excipients Used in Minipig Drug Development Studies".
Certain Helminths have been used for therapeutic purposes. Among others, Trichuris suis ova (TSO) have been demonstrated to exert a beneficial immunomodulatory effect in patients with immune-mediated diseases, such as inflammatory bowel disease. As described in the paper by N. Vejzagic et al. Göttingen minipigs have been used to assess the biological potency of TSO because of their small size, defined genetic background and well-known microbiological status.
Read more about this exciting study in the article: N. Vejzagic et al. Temperature dependent embryonic development of Trichuris suis eggsin a medicinal raw material. Veterinary Parasitology 215 (2016) 48–57
29 June - 1 July 2016
Anette Blak Grossi and Lars Friis Mikkelsen will be very pleased to meet you during the 43rd Annual Meeting of the Japanese Society of Toxicology (JSOT) in Nagoya, Japan, where Anette will give a presentation: “The use of Göttingen Minipigs in scientific research” and Lars a presentation: “The Göttingen Minipigs - Past, present and future global perspectives”.
We look forward to welcoming you in Japan!
On 26-27 May we attended the annual meeting of the Minipig Research Forum in Copenhagen where 20 speakers presented their Minipig knowledge and experience. The presentations covered the three topics: Immunology and vaccine testing in the Minipig, Minipig ophthalmology as well as Juvenile and embryofetal development studies in the Minipig.
The meeting had more than 100 attendees and was an excellent opportunity for us to learn more about the many different types of Minipig studies and procedures.
Presentations and further information from the meeting are available on the Minipig Research Forum website.
7 - 8th April, 2016 at Janssen R&D, Belgium
On Friday 8th April 2016, a session on “Progress in using the minipig as species in juvenile toxicology studies” will be held.This session will cover the following presentations:
Anette Blak Grossi and Jens Ellegaard will represent Ellegaard Göttingen Minipigs A/S at the 8th Juvenile Toxicity Symposium in Belgium. Please contact us for further information regarding minipigs in juvenile studies.
7th April, 2016 at Massachusetts Society for Medical Research, Boston, USA
Adrian Zeltner, Customer Support & Veterinary Services, will be very pleased to meet you during the 8th Annual Laboratory Animal Enrichment Symposium. You are invited to hear the oral presentation about the: “Swine Ethology And Behaviour – Welfare and Enrichment Examples for the Göttingen Minipigs”, by Adrian Zeltner on the 7th April, at 2:50 pm.
You can visit Adrian at Marshall booth, and discuss the latest developments and how you can work with Göttingen Minipigs.
We look forward to welcoming you in Boston!
Lars Friis Mikkelsen, Anette Blak Grossi and Jens Ellegaard will be very pleased to meet you during the Society of Toxicology's 55th Annual Meeting and ToxExpo in New Orleans, USA. We invite you to visit our booth with the opportunity to meet our team and discuss the latest developments at Ellegaard Göttingen Minipigs.
You are also invited to attend the oral presentation:
"Can We Learn More from Our Göttingen Minipig Toxicology Studies?". Tuesday, March 15, 2016, 1:30 PM to 2:30 PM, Room 205; Presented by: Ellegaard Göttingen Minipigs, Marshall BioResources and CiToxLAB Scantox.
"The Minipig as a Model for Preclinical Cardiac Safety Testing". Wednesday, March 16, 2016, 10:30 AM to 11:30 AM, Room 211; Presented by: Ellegaard Göttingen Minipigs and Marshall BioResources.
You can find more information about the Joint Exhibitor-Hosted Session here.
We look forward to welcoming you in New Orleans!
Suenderhauf, et al. has described a physiologically based pharmacokinetic model of adult minipigs and studies are proceeding to develop the PBPK model of the Göttingen Minipig. A study by Van Peer, E. et al. provides morphometric data of specific organs and gastrointestinal pH values in the Göttingen Minipig, which may be useful for integration in a juvenile PBPK model.
Read more about this exciting study in the article: Van Peer, E. et al. Organ data from the developing Göttingen minipig: first steps towards a juvenile PBPK model.
Adrian Zeltner, Customer Support & Veterinary Services, will be very pleased to meet you during the 2016 Congress of the Animal Technology.
We invite you to visit our booth and take the opportunity to meet Adrian, and discuss the latest developments and how you can work with Göttingen Minipigs.
We look forward to welcoming you at our booth!
To increase the knowledge about excipient tolerability in the minipig, Ellegaard Göttingen Minipigs A/S in collaboration with Novartis AG initiated a collaborative project with the purpose of summarizing the experience of numerous laboratories in a review paper.
Read more about this exciting study in the article: Weaver, M.L.et al.Vehicle Systems and Excipients Used in Minipig Drug Development Studies.
In a project sponsored by Ellegaard Göttingen Minipigs A/S by means of providing the minipigs, similar pharmacological and toxicological changes as reported in humans patients and in the dog were observed.
Read more about this exciting study in the article: Manno, R.A. et al. The minipig as a new model for the evaluation of doxorubicin-induced chronic toxicity.
We are happy to annonce our support to several charity organisations during the year 2015:
On Wednesday, 18th November 2015 we are holding a joint meeting with RTC, entitled “The Göttingen minipig in non-clinical toxicology: a leading non-rodent species accepted by all regulatory authorities".
The meeting will take place in Israel and main objectives of this Round Table are to discuss the latest developments related to minipigs in biomedical and translational research with an emphasis on non-clinical safety testing in the minipig. The full day lectures, presented by experts with long and recognized experience in preclinical studies, will deal with the assessment of the current status of use of the minipig in toxicology studies, as well as with the potential future strategies for the use of the minipig as alternative non-rodent animal model in toxicology.
Genome-based comparison of drug targets together with quantitative tissue expression analysis allows rational prediction of pharmacology and cross-reactivity of human drugs in animal models thereby improving drug attrition which is an important challenge in the process of drug development.
The article presents a new chromosome level based version of the Göttingen Minipig genome together with a comparative transcriptional analysis of tissues with pharmaceutical relevance as basis for translational research.
Read more about this exciting study in the article: Functional analysis and transcriptional output of the Göttingen minipig genome.
Our CEO Lars Friis Mikkelsen will be visiting American College of Toxicology, 36th Annual Meeting on November 8-11 in Nevada, USA. Our partner breeding Göttingen Minipigs for North America, Marshall Bio Resources are attending with an exhibition booth. You are welcome to ask for him at their booth #320 or write us an e-mail to make an appointment for a meeting.
Göttingen Minipigs have been available in Korea for some time. Supporting our customers in Korea, we and our partner Woojung is conducting a one day seminar about the role of Ellegaard Göttingen Minipigs in research. The seminar will feature both local presentations as well as lectures by Lars Friis Mikkelsen and Adrian Zeltner from Ellegaard in Denmark.
The following day Adrian Zeltner will also be holding a technical workshop: “Handling and dosing of the Göttingen Minipig”, where users will be receiving training in working with the minipigs.
Species selection should be based on pharmacokinetic studies and comparison between animals and humans in the way they metabolize xenobiotics, among others. Learn more about drug metabolism and distribution characteristics of the minipig in the article:
Dalgaard L.: "Comparison of minipig, dog, monkey and human drug metabolism and disposition". J Pharmacol Toxicol Methods 74 (2015) 80-92
Read more about the Göttingen Minipig and Acute-phase proteins in the article:
Christoffersen, B.Ø. et al.,: "Age- and Sex-Associated Effects on Acute-Phase Proteins in Göttingen Minipigs." Comparative Medicine, 2015, 65(4):333-341
When using the Göttingen minipig as a model for human genital tract infections or for safety testing of substances intended for intravaginal administration, knowledge about the vaginal environment and microflora is important.
A collaborative project between Copenhagen University, CiToxLAB Scantox and Ellegaard Göttingen Minipigs has elucidated the composition of the vaginal microbiota in prepubertal and sexually mature Göttingen Minipigs.
Read more about this exciting study in the article: The vaginal microbiome is stable in prepubertal and sexually mature Ellegaard Göttingen Minipigs throughout an Estrous Cycle.
Our team will be very pleased to meet you during the 51st Congress of the European Societies of Toxicology EUROTOX.
We invite you to visit our booth and take the opportunity to meet our team and discuss the latest developments and how you can work with Göttingen Minipigs.
We look forward to welcoming you in Porto!
Read about the diet-induced atherosclerotic minipig model and the influence of STZ-induced diabetes on arterial intimal lesions and circulating inflammatory markers in the article:
Ludvigsen, T.P. et al. Göttingen minipig model of diet-induced atherosclerosis: influence of mild streptozotocin-induced diabetes on lesion severity and markers of inflammation evaluated in obese, obese and diabetic, and lean control animals. J Transl Med (2015) 13:312
Our team will be very pleased to meet you during the 53rd Annual Meeting of the Society for Laboratory Animal Science GV-SOLAS.
We invite you to visit our booth and take the opportunity to meet our team and discuss the latest developments and how you can work with Göttingen Minipigs.
You are also invited to hear the oral presentation:“Blutentnahmetechniken beim Göttingen Minipig” by Adrian Zeltner on the 16th September.
We look forward to welcoming you in Hanover!
How do minipig models rank in the research world?
Are they a good 3Rs alternative to other large animal models?
The ICH recognizes minipigs as a non-rodent species in preclinical tox studies. So why is this large animal not used more extensively?
Read more from blog written by Peter Mansell - the Associate Scientific Director of the General Toxicology Department at Charles River Laboratories' preclinical site in Montreal.
Spermatic cords from Göttingen minipigs are used in a project on the development of a medical device for non-surgical and reversible sterilization of men.
Follow the link below from Danish television for more information about the project.
Unfortunately, the news is only in Danish.
We have arranged two joint exhibitor-hosted sessions for the SOT meeting: "Reproductive and juvenile studies in minipigs" and The Göttingen Minipig as experimental model for Anti-neoplastic drug toxicity".
Lars Friis Mikkelsen has been appointed as the new CEO of Ellegaard Göttingen Minipigs. Lars has much experience from the pharmaceutical industry as he has worked for Novo Nordisk and Merck/MSD.
The new Newsletter can be downloaded and it includes several informative articles.
We are pleased to announce that our facility has once again been fully AAALAC accredited.
Our joint SOT exhibitor-hosted session with CiToxLAB on "The Minipig as a Model for Ocular Toxicity Studies" included three presentations: The Comparative Anatomy of the Minipig Eye; Administration and Sampling Techniques; and Routine and Specialised Evaluation Techniques.
The Minipig Research Forum is organising a joint meeting with the BSTP and ACCP where the main topic will be Rational selection of the Non-Rodent Species: Toxicology, Pathology and Relevance to Man. The meeting will take place on 13-14 November and will include several minipig presentations.
At the SOT ToxEXPO meeting in Phoenix, Arizona we had a joint exhibitor-hosted session with Huntingdon Life Sciences. The session included three informative presentations on the practicalities of juvenile, inhalation and safety pharmacology studies in the minipig.
The new newsletter includes articles on ocular lesions, thermal burn modeling, cerebrospinal fluid collection, central venous catheterisation by jugular vein placement, catheterisation of the genital tract and the genomic considerations when selecting a model organism.
At the SOT ToxEXPO meeting in Phoenix, Arizona we will have two joint exhibitor-hosted sessions with Huntingdon Life Sciences and CiToxLAB.
In January 2014 Ellegaard Göttingen Minipigs has signed an agreement with Woojung BSC which means that Göttingen Minipigs are now available for research in South Korea.
Two new articles on blood sampling and enrichment describe how the work with minipigs can be further refined.
We have delivered a Göttingen Minipig breeding herd to Oriental Yeast Co. in Japan. The Göttingen Minipig is now bred in Japan for delivery to Japanese Companies and universities.
Now you can follow Ellegaard Göttingen Minipigs on LinkedIn.
From March 2013 Ellegaard Göttingen Minipigs has a new logo:
The new newsletter contains informative articles about...
On 18-19 November we attended the annual meeting of the Minipig Research Forum where 17 speakers presented their minipig knowledge.
The new newsletter contains informative articles about...