EVENTS

The Minipig as a Translational Animal Model

Booth: - Location:Cambridge, USA

Scientific Meeting

Jun 09, 2022 | 4 pm EDT

The Minipig as a Translational Animal Model

Booth: - Location:Cambridge, USA

How do we address the increasing need for translational animal models? Join us as we discuss the future of minipigs.

ACT Annual Meeting

Booth: - Location:Denver, Colorado, USA

Scientific Meeting

Nov 13, 2022 - Nov 16, 2022 | 08:00

ACT Annual Meeting

Booth: - Location:Denver, Colorado, USA

The mountains are calling you to the ACT 43rd Annual Meeting, to be held at the Gaylord Rockies in Denver, Colorado, November 13–16, 2022.

AALAS National Meeting 2022

Booth: - Location:Louisville, Kentucky, USA

Scientific Meeting

Oct 23, 2022 - Oct 27, 2022 | 08:00

AALAS National Meeting 2022

Booth: - Location:Louisville, Kentucky, USA

More information to come.

SPS Annual Meeting

Location:Montreal, Canada

Scientific Meeting

Sep 11, 2022 - Sep 14, 2022 | 08:00

SPS Annual Meeting

Location:Montreal, Canada

More information to come.

Göttingen Minipigs with reduced SORL1 expression models Alzheimer´s disease

Webinar

May 03, 2022 | 3 pm

Göttingen Minipigs with reduced SORL1 expression models Alzheimer´s disease

Alzheimer’s disease (AD) affects an estimated 40 millions patients worldwide and is still without any cure despite decades of research and billions of dollars spent trying to develop pharmacological interventions. The reasons for this failure are heavily debated in the field, but there is consensus that part of the explanation is the translational gap between promising studies conducted in cells and mouse models and clinical trials aiming at curing or alleviating this complex brain disorder in humans. In this webinar, Olav M. Andersen and Charlotte B. Sørensen from Aarhus University in Denmark will present their novel Göttingen SORL1-deficient Minipigs model which authentically mimics the genetic makeup of AD patients with hemizygous loss of SORL1 expression.

Training of minipigs to ensure stressfree handling and better science

Speakers:Stine Drent Larsen, Animal Caretaker at Novo Nordisk

Webinar

Mar 03, 2022 | 3 PM

Training of minipigs to ensure stressfree handling and better science

Speakers:Stine Drent Larsen, Animal Caretaker at Novo Nordisk

Novo Nordisk has chosen as a daily task to train the minipigs for various procedures in order to improve the working environment for the employees, decrease anxiety and stress in the minipigs, and ultimately to ensure better and reliable science.

EUROTOX - ICT 2022

Booth: - Location:Maastricht, Netherlands

Scientific Meeting

Sep 18, 2022 - Sep 21, 2022 | 08:00

EUROTOX - ICT 2022

Booth: - Location:Maastricht, Netherlands

This congress is jointly organized with the International Union of Toxicology (IUTOX) and the European Society of Toxicology (EUROTOX), and unites the best of toxicological scientists worldwide in the historical city of Maastricht. 

FELASA 2022

Booth: - Location:Marseille, France

Scientific Meeting

Jun 13, 2022 - Jun 16, 2022 | 08:00

FELASA 2022

Booth: - Location:Marseille, France

The motto of this FELASA Congress is COMMUNICATION. This central theme will lead through various content streams: communication between animals, between animals and humans, between fellow researchers, between trainers and trainees, between laboratory Animal Science specialists at all levels and the Society. 

SBR 2022

Booth: - Location:Madison, Wisconsin, USA

Scientific Meeting

Jun 10, 2022 - Jun 14, 2022 | 08:00

SBR 2022

Booth: - Location:Madison, Wisconsin, USA

SBR 2022 marks the coming era of translational research in pigs, that promises to accelerate the discovery and development of clinically relevant therapies and technologies.

IAT Congress 2022

Booth: - Location:Harrogate Convention Centre

Scientific Meeting

Mar 29, 2022 - Apr 01, 2022 | 08:00

IAT Congress 2022

Booth: - Location:Harrogate Convention Centre

More information to come.

SOT 2022

Booth: 1715 Location:San Diego, USA

Scientific Meeting

Mar 27, 2022 - Mar 31, 2022 | 08:00

SOT 2022

Booth: 1715 Location:San Diego, USA

More information to come.

Göttingen Minipigs - a new model for gut microbiome studies

Webinar

Nov 30, 2021 | 15:00

Göttingen Minipigs - a new model for gut microbiome studies

In 2021, a business/university consortium received funding from the Innovation Fund Denmark to develop translational animal models for inflammatory bowel disease in man. The focus will be on induction of intestinal inflammation and characterising the dynamics of the gut microbiome of various pre- and probiotic intervention. The project combines two omnivore animal models (insects: Fast and inexpensive screening; Minipigs: Highly predictive) for preclinical research on pipeline formulations in biotech and pharma intended for microbiome stimulation and treatment of chronic intestinal disorder in humans. In this presentation preliminary observation will be presented by Professor Christian Kapel, University of Copenhagen, Denmark. Please find more information about the project on www.minigut.dk

TEST internal 18-10-2021

Webinar

Oct 18, 2021 | 11:30

TEST internal 18-10-2021

This is a test session to make sure you feel safe using the platform, and all hardware (headphones, mics, etc.) work properly.

3R's Research and Progress

Location:Hyderabad, India

Scientific Meeting

Nov 18, 2021 - Nov 19, 2021 | 08:00

3R's Research and Progress

Location:Hyderabad, India

More information to come.

Joint Scientific Symposium by ERBC and Ellegaard Göttingen Minipigs

Location:Rome, Italy

Scientific Meeting

Oct 28, 2021 | 08:00

Joint Scientific Symposium by ERBC and Ellegaard Göttingen Minipigs

Location:Rome, Italy

Attend this scientific symposium with an interesting scientific program, incl. presentations by our CEO, Lars Friis Mikkelsen, Head of International Sales, Peter Vestbjerg, and CSO, Kirsten Rosenmay Jacobsen.

Flanders Vaccine: Immunity for Health 2021

Location:Ghent, Belgium

Scientific Meeting

Oct 14, 2021 | 08:00

Flanders Vaccine: Immunity for Health 2021

Location:Ghent, Belgium

Visit our stand for a chat with our Head of International Sales, Peter Vestbjerg, or our CEO, Lars Friis Mikkelsen.

Refinements in Minipig Inhalation Toxicology

Webinar

Oct 26, 2021 | 14:00

Refinements in Minipig Inhalation Toxicology

Minipig inhalation is an emerging field in toxicology due to their homology to humans. In this webinar, Alice McNamara MRCVS from Labcorp will share how the Labcorp team has successfully completed several regulatory toxicology studies using this model, and have implemented multiple welfare refinements including: • Training. Design of a bespoke positive reinforcement training protocol to acclimatise animals to staff, training them to walk in a harness to the dosing suite and then tolerate wearing a mask for up to 120 minutes/session. • Physical environment. From 3D printing masks in a variety of sizes to give a comfortable fit and minimise dead space, to optimising the dosing suite for pig comfort with tactile, auditory and olfactory enrichment, the environment of the dosing suite allowed animals to calmly settle and even fall asleep during dosing procedures. • Safety monitoring. The safety of the animals is paramount in any study, so capnography and visual scoring to monitor the animals continuously was employed.

Göttingen Minipigs as a Model to Evaluate Longevity, Functionality and Memory of Immune Response Induced by Pertussis Vaccines

Webinar

Oct 07, 2021 | 15:00

Göttingen Minipigs as a Model to Evaluate Longevity, Functionality and Memory of Immune Response Induced by Pertussis Vaccines

Evaluation of the short-term and long-term immunological responses in a preclinical model that simulates the targeted age population with a relevant vaccination schedule is essential for human vaccine development. A neonatal and infant Göttingen Minipig model using whole cell and acellular pertussis vaccines was developed to assess antigen-specific humoral and cellular responses in a longitudinal study. The main immune parameters tested included total IgG, functional antibodies, Th cell subsets and memory T and B cells. Single cell RNA sequencing was used to explore the long-term maintenance of circulating immune memory cells and their functionality. Overall, the minipig model reproduced the immune responses induced in humans by whole cell versus acellular pertussis vaccine priming, followed by acellular pertussis vaccine boosting. Associate Scientist Céline Vaure, from Sanofi Pasteur in France, will present results suggesting that Göttingen Minipigs are an attractive preclinical model to predict the long-term immunogenicity of human vaccines against Bordetella pertussis and that it could be of further interest for vaccines against other pathogens.

Pig models for human nutrition research

Webinar

Jun 29, 2021 | 08:00

Pig models for human nutrition research

Pigs are of interest in human nutritional research because of similarities in the genome, anatomy, digestive physiology, and body size to humans. Pigs are therefore increasingly being used to understand the exact mechanisms behind the role in progression or prevention of disease. Like humans, pigs are omnivores, and in an experimental setting, they can be fed human-like energy-dense diets high in refined carbohydrates and fat and low in dietary fiber. The domestic pig is relevant for studying digestion, bioconversion, and absorption of diet-derived metabolites, but for the metabolic response to dietary intervention in relation to obesity-related diseases, miniature pigs serve better models. In this webinar, Professor Knud Erik Bach Knudsen, Senior Scientist Helle Nygaard Lærke, and Postdoctoral Researcher Mihai Curtasu will present and discuss studies in conventional and Göttingen Minipigs on the effect of diet composition in obesity development and mitigation particularly emphasizing the role of the diet-microbiota interaction.

Göttingen Minipigs and Xenotransplantation

Webinar

Aug 26, 2021 | 13:00

Göttingen Minipigs and Xenotransplantation

Xenotransplantation is under development in order to alleviate the shortage of human transplants. For numerous reasons, pigs are the best donor animals. However, the use of pig cells or organs may be associated with the transmission of zoonotic viruses. In this webinar, Dr. Joachim Denner, from Institute of Virology Free University Berlin in Germany, explains the extensive analysis of Göttingen Minipigs, which will be used for the treatment of human diabetes patients in Germany in near future. Using sensitive PCR-based and immunological methods, in some animals hepatitis E virus (HEV), porcine cytomegalovirus (PCMV), and porcine circovirus 2 (PCV2) were found. In addition, porcine endogenous retroviruses (PERV-A, -B, and -C) were found integrated in the genome of all Göttingen Minipigs. However, when islet cells from Göttingen Minipigs were transplanted into cynomolgus monkeys, no transmission of PERV and other porcine viruses was observed. Whereas HEV, PCMV, and PCV2 can be successfully eliminated by antiviral drugs, early weaning, or a vaccine, first experiments to inactivate PERVs using CRISPR/Cas have been reported. 

Using Göttingen minipigs at Ellegaard to test a new antiviral (anti-SARS-CoV-2) inhalation drug

Webinar

Sep 15, 2021 | 08:00

Using Göttingen minipigs at Ellegaard to test a new antiviral (anti-SARS-CoV-2) inhalation drug

A new anti-viral, including anti-SARS-CoV-2, inhalation drug has been tested for safety at Ellegaard Göttingen Minipigs A/S in a collaboration between Ellegaard Göttingen Minipigs, University of Copenhagen, and the Norwegian company (owning the patent) SoftOx. First the drug was tested in an intubated minipig model to maximize lung exposure; the animals were thus anaesthetized and received the nebulised drug once daily for five days. Subsequently a masked inhalation model in slightly sedated minipigs was developed to also test upper airway exposure. Göttingen Minipigs are relevant models for inhalation therapy as they in many ways resemble human respiration physiology and anatomy. Mild dose-dependent changes were seen on histopathology in the highest dosing groups. During the experiments all animals were clinical well and tolerated the experiment fine. Experimental design and experiences are presented by Professor Thomas Bjarnsholt, University of Copenhagen, also consultant for SoftOx, and DVM and postdoc Elin Jørgensen, University of Copenhagen (SoftOx grant).

Optical coherence tomography (OCT) for ocular safety assessment in Göttingen Minipigs

Webinar

Sep 29, 2020 | 12:00

Optical coherence tomography (OCT) for ocular safety assessment in Göttingen Minipigs

Optical coherence tomography (OCT) has become a standard diagnostic tool in ophthalmology and has gained increasing importance also in preclinical ocular safety assessment. It is a non-invasive technique and provides real-time cross-sectional images of ocular structures. In this webinar, Dr. Nora Denk, F. Hoffmann-La Roche Ltd, will share current use of this technique and provide an outlook for ongoing and future developments and possibilities for ocular safety assessments in Göttingen Minipigs.

Inhalation studies in minipigs

Webinar

Oct 20, 2020 | 08:00

Inhalation studies in minipigs

There has been a slow uptake to use minipigs as an alternative second species for inhalation studies, which is in part due to technical challenges, but also the historical classes of test articles being used such as beta-agonists, corticosteroids, anti-muscarinic for asthma and COPD, where the dog has been the species of choice based on available background data. However, with ongoing focus and debate on second species selection actively requesting the industry to equally consider all species and in many ways especially minipigs, there is now greater support for the minipig to be used more frequently. Global Lead of Inhalation Sciences and Engineering, Simon Moore from Covance will discuss this opportunity, which is further supported by evidence, where the inhalation delivery route is now being used for respiratory diseases such as cystic fibrosis and idiopathic pulmonary fibrosis with novel compound classes or re-purposing from other routes of administration.

Minipigs in translational immunosafety assessment

Webinar

Nov 19, 2020 | 09:30

Minipigs in translational immunosafety assessment

The challenge for immunosafety assessment remains the interpretation-uncertainty of changes of selected immunological endpoints when assessing immunocompetence and immune dysregulation. Minipigs have received attention as alternative species to dogs and Non-Human Primates in immunosafety assessment; and recent comparative immunological studies in Göttingen Minipigs with other species have investigated and broadened the translational value of minipigs as an animal model in drug safety evaluations. In this webinar, Tina Rubić-Schneider and Michael Kammüller, Novartis Institutes for BioMedical Research (NIBR), will discuss aspects of the translational significance of Göttingen Minipigs in immune-safety assessment.

Development of a urinary tract infection animal model in Göttingen Minipigs

Webinar

Dec 03, 2020 | 14:00

Development of a urinary tract infection animal model in Göttingen Minipigs

Urinary tract infections (UTIs) remain an unmet medical need as E. coli is the leading cause of bacteremia in the elderly, often starting as a UTI. Rodent models are inadequate because of the volume and route of the bacterial inoculum used to start the infection. Jeffrey Fernandez, Senior Scientist, and Jessica Henn, Associate Scientist at Janssen Research & Development, will share results of initial experiments that may suggest that Göttingen Minipigs could serve as a promising animal model to predict the efficacy of agents to fight UTIs.

Hypersensitivity reactions to nano-biopharmaceuticals: Foundation of a minipig model

Webinar

Jan 12, 2021 | 09:00

Hypersensitivity reactions to nano-biopharmaceuticals: Foundation of a minipig model

Acute hypersensitivity reactions to intravenously administered nano-biopharmaceuticals, also known as Infusion Reactions (IRs), are complex, innate immune reactions arising from a variable combination of complement (C) activation and triggering of pattern recognition receptors on allergy mediating cells. Pigs, due to the presence of intravascular macrophages in the microcirculation of their lungs, called PIM cells, provide a sensitive model for studying the most dangerous, occasionally life-threatening cardiovascular response leading to anaphylactoid shock and death. Janos Szebeni, CEO at SeroScience Ltd. in Hungary, presents highlights of the clinical and pharmaco-industrial relevance of this problem and discusses the benefits of pigs compared to other animals in consistently reproducing human symptoms. Beyond detailing the conditions, mechanism, and prevention of IRs clarified in domestic pigs, the presentation will give an account of experiments in Göttingen Minipigs that suggest their suitability as a model for drug-induced IRs with all advantages for regulatory standardization. Other focal points will include immunogenicity of nano-biopharmaceuticals and anti-PEG antibodies.

Anticancer drug development comparison of toxicity in minipig and mouse

Webinar

Feb 03, 2021 | 09:00

Anticancer drug development comparison of toxicity in minipig and mouse

This presentation gives a brief overview of anti-cancer drug development and discusses how the selection of the most appropriate preclinical species can help in predicting safe but potentially efficacious clinical starting doses. Using data from recent toxicity studies in the mouse and minipig on a novel anti-cancer therapeutic, Sally-Anne Reynolds, Toxicology Manager at Sequani Limited, describes how results obtained from studies in minipigs appeared to better predict potential adverse effects in humans, in terms of the nature of the effects and the dose levels at which they occurred.

Drug metabolism in Göttingen Minipigs: Critical information for species selection in drug safety testing

Webinar

Feb 24, 2021 | 09:00

Drug metabolism in Göttingen Minipigs: Critical information for species selection in drug safety testing

Safety pharmacology, toxicology and pharmacokinetic (PK) data are critical in drug development to provide safety and exposure information for the clinical studies. For optimal species selection in the nonclinical studies, metabolite profiling and plasma protein binding are key PK data to be considered. Metabolites can be investigated in several in vitro matrices, including hepatocytes, subcellular fractions of liver (microsomes, S9), recombinant enzymes, as well as in vivo. As all of these in vitro matrices, except recombinant enzymes, are commercially available for Göttingen Minipigs, it is surprising that this species is still not routinely included in the in vitro drug metabolism testing battery of most pharmaceutical companies. In this presentation, Steven Van Cruchten, Professor in Comparative Perinatal Development at the University of Antwerp, will focus on drug metabolism in adult and juvenile minipigs together with their relation to other non-rodent species and man.

Imaging techniques for Göttingen Minipigs with PET, MRI and CT

Webinar

Mar 16, 2021 | 09:00

Imaging techniques for Göttingen Minipigs with PET, MRI and CT

Imaging has become widespread in preclinical research and techniques for scanning Göttingen Minipigs have also proved to be extremely relevant. In this webinar, Aage Kristian Olsen Alstrup, from Aarhus University Hospital in Denmark, reviews the possibilities of scanning Göttingen Minipigs using different techniques: PET (positron emission tomography), MRI (magnetic resonance imaging), and CT (computerized tomography) scanning. The advantages and challenges of each scanning modality will be assessed from a practical perspective and the importance of anesthesia, surgical techniques, placement of pigs in the scanner, monitoring, administration of tracers, and possible post scanning complications will be reviewed as well.

Induction of prediabetes and diabetes in adult obese Göttingen Minipigs

Webinar

Apr 15, 2021 | 08:00

Induction of prediabetes and diabetes in adult obese Göttingen Minipigs

To follow the natural course of obese type 2 diabetes in an adult Göttingen Minipig model, the pig needs to become obese first and subsequently develop diabetes. Once insulin-resistant obesity is established in adult Göttingen Minipigs by ad libitum feeding of a high energy Western diet, diabetes should evolve after a certain period of time. The capacity of pancreatic beta-cells to produce sufficient insulin to compensate for insulin resistance becomes limited and, as a result, blood glucose concentrations increase. However, pigs do not easily develop (pre)diabetes spontaneously, at least not in the time frame of 1 or 2 years after the induction of severe obesity. To accelerate the development of diabetes in obese Göttingen Minipigs, streptozotocin can be used to chemically reduce the pancreatic beta-cell mass in order to elevate blood glucose concentrations. In this webinar, Sietse Jan Koopmans from Livestock Research at Wageningen University & Research in The Netherlands, will discuss various strategies to induce prediabetes and diabetes in adult obese Göttingen Minipigs by repeated intravenous administration of streptozotocin.

The use of Minipigs in juvenile toxicity testing

Webinar

Apr 28, 2021 | 08:00

The use of Minipigs in juvenile toxicity testing

Göttingen Minipigs have become popular as a non-rodent species in routine repeat dose safety testing during the last few years and is also a promising model for juvenile toxicity studies. For pediatric indications requiring juvenile toxicity testing, the rat is still the preferred species because it is the most convenient and widely studied species with extensive historical control data and well-established testing methods. However, for some drugs it might not be an appropriate model or regulatory agencies may request both rodent and non-rodent juvenile studies, for example in case of pediatric-only indications. The minipig represents good similarity to man in terms of many organ systems, including their post-natal development. The most common non-rodent species for juvenile studies is still the dog, but the minipig has many practical advantages over the dog and monkey. Due to the relevant recent use of minipigs in this field, only a limited number of studies have been conducted within each age category (with commencement of dosing at different ages) and therefore background data are limited. In this webinar, Bianca Feyen, Toxicologist at Janssen in Belgium, will discuss the advantages of using minipigs in juvenile toxicity testing and provide an overview of available background data.

Application of Göttingen Minipigs biological material in In Vitro studies

Webinar

May 27, 2021 | 08:00

Application of Göttingen Minipigs biological material in In Vitro studies

In this webinar, Dr. Julia Lodder-Gadaczek, Head of Laboratory PhA skin lab at LTS Lohmann Therapiesysteme AG in Germany, and Anette Sams Nielsen, Senior Scientist at Copenhagen University Hospital in Denmark, will share and discuss their experiences using biological material from Göttingen Minipigs. Julia Lodder-Gadaczek: For the development of a transdermal therapeutic system (TTS) in vitro permeation experiments are used as models for the penetration of a drug through the skin to the vesicular system. These experiments are necessary to generate information about the properties of a new formulation in terms of drug penetration, kinetic profile of permeation, and needed concentration levels of the drug. The barrier in this model is normally built by skin and for the early development stage of a new TTS the skin of Göttingen Minipigs is a useful model. In this webinar, the principle of the experiment, the preparation of the skin and the advantages and potential risks of using Göttingen Minipigs skin as a model for in vitro permeation trials will be discussed. Anette Sams Nielsen: Minipigs are superior animal models for human health and diseases with cardiovascular anatomy and physiology similar to humans. Rodent models of neurovascular and endothelial regulation of vascular tone have been thoroughly studied in vivo and ex vivo and do not always offer good translation to sparse human vascular biopsies available from surgery and biopsies. The size of Göttingen Minipigs allows us to dissect sufficient artery segments for thorough characterization, pairing and comparison using a very limited number of animals (3Rs). The aim of the current study was to characterize regulation of vascular tone in Göttingen Minipigs by selected agonists for sympathetic, parasympathetic, sensory and endothelial pathways and to compare vasomotor responses of coronary, cerebral and peripheral arteries using myographs. We will share our data and discuss the scientific and practical issues of studying minipig and rodent vasomotor actions.

Inhalation therapy for heart failure with reduced ejection fraction in Göttingen Minipigs

Webinar

Jun 10, 2021 | 08:00

Inhalation therapy for heart failure with reduced ejection fraction in Göttingen Minipigs

Peptide-based therapies are at the forefront of therapeutic innovations in the cardiovascular field. However, the lack of a non-invasive administration route to the heart represents a challenge for the translation of preclinical compounds into the clinical arena. Dr. Alessio Alogna, Clinician Scientist from Charité Universitätsmedizin Berlin, will give some insights into a proof-of-concept, translational study recently performed in Göttingen Minipigs by his research group. This study investigated the efficacy of a novel therapy based on inhalation of peptide-loaded biocompatible calcium phosphate nanoparticles in tachypacing-induced heart failure with reduced ejection fraction (HFrEF).

AFSTAL

Booth: - Location:Marseille, France

Scientific Meeting

Nov 30, 2021 - Dec 02, 2021 | 08:00

AFSTAL

Booth: - Location:Marseille, France

More information to come.

EUROTOX

Booth: Virtual stand

Scientific Meeting

Sep 27, 2021 - Oct 02, 2021 | 08:00

EUROTOX

Booth: Virtual stand

Ellegaard Göttingen Minipigs will be present at the 11th World Congress with a virtual stand.

Our CEO, Lars Friis Mikkelsen, will be chair in session 05 "The Use of Minipigs in Juvenile Studies in an Evolving Regulatory Landscape".

GV-Solas IGTP

Booth: Virtual stand

Scientific Meeting

Sep 22, 2021 - Sep 25, 2021 | 08:00

GV-Solas IGTP

Booth: Virtual stand

Ellegaard Göttingen Minipigs will be present at the 11th World Congress with a virtual stand.

World Congress 11

Booth: Virtual stand Speakers:CEO at Ellegaard Göttingen Minipigs, Lars Friis Mikkelsen

Scientific Meeting

Aug 23, 2021 - Sep 02, 2021 | 08:00

World Congress 11

Booth: Virtual stand Speakers:CEO at Ellegaard Göttingen Minipigs, Lars Friis Mikkelsen

Ellegaard Göttingen Minipigs will be present at the 11th World Congress with a virtual stand.

Our CEO, Lars Friis Mikkelsen, is an invited speaker at session 221 on the topic "Implementing the Three Rs in the creation and breeding of Genetically Altered Animals (GAAs)s".

Also, our Animal Welfare Technician, Carina Christoffersen, and our Head of Scientific Management, Kirsten Rosenmay Jacobsen, will present a poster on "Blood sampling from Göttingen Minipigs - implementing a refined blood sampling technique".

Application of Göttingen Minipigs biological material in In Vitro studies

Booth: M4876

Webinar

Jun 23, 2022 |

Application of Göttingen Minipigs biological material in In Vitro studies

Booth: M4876

In this webinar, Dr. Julia Lodder-Gadaczek, Head of Laboratory PhA skin lab at LTS Lohmann Therapiesysteme AG in Germany, and Anette Sams Nielsen, Senior Scientist at Copenhagen University Hospital in Denmark, will share and discuss their experiences using biological material from Göttingen Minipigs.

Julia Lodder-Gadaczek: For the development of a transdermal therapeutic system (TTS) in vitro permeation experiments are used as models for the penetration of a drug through the skin to the vesicular system. These experiments are necessary to generate information about the properties of a new formulation in terms of drug penetration, kinetic profile of permeation, and needed concentration levels of the drug. The barrier in this model is normally built by skin and for the early development stage of a new TTS the skin of Göttingen Minipigs is a useful model. In this webinar, the principle of the experiment, the preparation of the skin, and the advantages and potential risks of using Göttingen Minipigs skin as a model for in vitro permeation trials will be discussed.

Anette Sams Nielsen: Minipigs are superior animal models for human health and diseases with cardiovascular anatomy and physiology similar to humans. Rodent models of neurovascular and endothelial regulation of vascular tone have been thoroughly studied in vivo and ex vivo and do not always offer good translation to sparse human vascular biopsies available from surgery and biopsies. The size of Göttingen Minipigs allows us to dissect sufficient artery segments for thorough characterization, pairing, and comparison using a very limited number of animals (3Rs). The aim of the current study was to characterize regulation of vascular tone in Göttingen Minipigs by selected agonists for sympathetic, parasympathetic, sensory, and endothelial pathways and to compare vasomotor responses of coronary, cerebral, and peripheral arteries using myographs. We will share our data and discuss the scientific and practical issues of studying minipig and rodent vasomotor actions.

SpåraKoff Tram Through Helsinki - Celebrating The First 50 Years With Göttingen Minipigs at Eurotox 2019

Location:Tram Stop No. 0105 on E12 at Finlandia Hall. Pls note the line direction as marked on the map)

Scientific Meeting

Jun 23, 2022 |

SpåraKoff Tram Through Helsinki - Celebrating The First 50 Years With Göttingen Minipigs at Eurotox 2019

Location:Tram Stop No. 0105 on E12 at Finlandia Hall. Pls note the line direction as marked on the map)

On the occassion of the 50-year anniversary of Göttingen Minipigs, we invite you to take part in a networking event and join us in an exclusive tour on the SpåraKoff Tram.

The iconic tram will take us on a private tour through Helsinki while offering the opportunity to network with colleagues, users and friends of Göttingen Minipigs. Drinks and snacks will be served on the tour, which ends in time for the City Hall Reception at 19:00.

Participation is free of charge, but only a limited number of seats are available so don’t hesitate to save yours.

Please also stop by our Booth No. 7 at Finlandia Hall.

We look forward to seeing you in Helsinki!

Click here to get the invitation including maps

Scientific Symposium - 50 Years with Göttingen Minipigs, Paris France

Location:Sanofi

Webinar

Jun 23, 2022 |

Scientific Symposium - 50 Years with Göttingen Minipigs, Paris France

Location:Sanofi

Invitation

The year of 2019 marks the first 50 Years with Göttingen Minipigs since the Georg-August-University in Göttingen, Germany, managed to establish the first barrier-bred population of Göttingen Minipigs at the University’s experimental farm in Relliehausen, Germany.
Ellegaard Göttingen Minipigs is the global breeder and developer of Göttingen Minipigs, and on behalf of our whole team, I am pleased to invite users of and friends with an interest in Göttingen Minipigs to this Scientific Symposium in celebration of the first 50 years with Göttingen Minipigs.

Prominent scientists will present their work and results obtained by the use of Göttingen Minipigs, and there will also be time for networking during the day. Get the full program with route map here. Participation including lunch and networking drinks is free.

We hope to see you as our guest!

Best regards Lars

Friis Mikkelsen
CEO

Soroe Landevej 302
DK-4261 Dalmose
Denmark

Phone+45 5818 5818
Email lfm@minipigs.dk
www.minipigs.dk
LinkedIn company page

Scientific Symposium - 50 Years with Göttingen Minipigs, Basel Switzerland

Location:Novartis Pharma, Main Campus

Scientific Meeting

Jun 23, 2022 |

Scientific Symposium - 50 Years with Göttingen Minipigs, Basel Switzerland

Location:Novartis Pharma, Main Campus

Invitation

The year of 2019 marks the first 50 Years with Göttingen Minipigs since the Georg-August-University in Göttingen, Germany, managed to establish the first barrier-bred population of Göttingen Minipigs at the University’s experimental farm in Relliehausen, Germany. Ellegaard Göttingen Minipigs is the global breeder and developer of Göttingen Minipigs, and on behalf of our whole team, I am pleased to invite users of and friends with an interest in Göttingen Minipigs to this Scientific Symposium in celebration of the first 50 years with Göttingen Minipigs.

Prominent scientists will present their work and results obtained by the use of Göttingen Minipigs, and there will also be time for networking during the day. Get the full program with route map here. Participation including lunch and networking drinks is free.

We hope to see you as our guest!
Best regards
Lars Friis Mikkelsen
CEO



Soroe Landevej 302
DK-4261 Dalmose
Denmark

Phone+45 5818 5818
Email lfm@minipigs.dk
www.minipigs.dk
LinkedIn company page

Pain models in Göttingen Minipigs - bridging the gap between rodents and humans

Booth: MP4876 Location:San Francisco, California USA

Webinar

May 14, 2020 | 08:00

Pain models in Göttingen Minipigs - bridging the gap between rodents and humans

Booth: MP4876 Location:San Francisco, California USA

Traditional rodent models have contributed significantly to our understanding of pain and pain mechanisms, but improving the animal models in these studies has become critical for developing safe and effective pain therapies. Sigal Meilin, Chief Scientific Officer at MD Biosciences, will share learnings from their study on pain models in Göttingen Minipigs, and how this species can bridge knowledge from pain studies in rodents and humans.

The role of Göttingen Minipigs in dermal drug development

Webinar

Jun 16, 2020 | 08:00

The role of Göttingen Minipigs in dermal drug development

For all drug development programs, it is vital that the non-clinical studies are appropriately designed. This includes the correct choice of species, also taking the route of administration into consideration. In the case of dermal application of drugs, Göttingen Minipigs is the species of choice, and in this webinar, Andy Makin will share his decades of experience and huge knowledge in this specialized field of biomedical research.

Characterisation of the porcine immune system with a focus on Göttingen Minipigs

Webinar

Jul 02, 2020 | 08:00

Characterisation of the porcine immune system with a focus on Göttingen Minipigs

Göttingen Minipigs are widely used by pharmaceutical companies for the development of new medicines including toxicology studies and safety assessment, but the knowledge about their immune system is still scarce. Professor, Dr. Armin Saalmüller, Chair of the Institute of Immunology at VetMedUni Vienna, Austria, and Ph.D. student, Clara Pernold, will in the Webinar provide insight into combining the existing knowledge about the porcine immune system with immunological questions relating to the use of Göttingen Minipigs in preclinical studies.

Göttingen Minipigs genetics: Breed history, breeding strategies and genome analyses

Booth: MP4876 Location:Anaheim, California USA

Webinar

Aug 26, 2020 | 08:00

Göttingen Minipigs genetics: Breed history, breeding strategies and genome analyses

Booth: MP4876 Location:Anaheim, California USA

As presented in a recent publication, genomic analysis can be a powerful tool to manage inbreeding and breed integrity in a small population, such as Göttingen Minipigs. Christian Reimer, from the University of Göttingen, shares how breeding shaped Göttingen Minipigs and what genome analysis can tell us about its current state.

The pig as a large preclinical model for therapeutic human anti-cancer vaccine development

Location:Ellegaard Göttingen Minipigs A/S, Dalmose, Denmark

Webinar

Sep 10, 2020 | 08:00

The pig as a large preclinical model for therapeutic human anti-cancer vaccine development

Location:Ellegaard Göttingen Minipigs A/S, Dalmose, Denmark

New porcine experimental animal models, that are genetically engineered to develop spontaneous tumors upon injection of genetic triggers, offer exciting new opportunities to study different phases of cancer immunoediting in immunocompetent large animal hosts. Gregers Jungersen, Professor in Veterinary Vaccine Research at SSI in Copenhagen, will share findings from the immunological landscape of such tumors in “Oncopig” studies performed in collaboration with the University of Illinois and discuss how minipigs may be used to increase the success rate of preclinical studies in cancer research.

Background Pathology in Göttingen Minipigs

Scientific Meeting

Jun 23, 2022 | T14:00:00Z

Background Pathology in Göttingen Minipigs

When performing toxicology studies, knowledge of the background pathology is extremely important and for Göttingen Minipigs much is known and has been published. Sean McKeag from Covance will present an overview, including what especially to be aware of, and give a status on the upcoming INHAND guidance document for standardized nomenclature. The 30 min webinar will end with a Q&A session based on questions submitted “on-line” during the talk.

Göttingen Minipigs in human relevant safety assessment - learnings from Roche (Safety Pharmacology and Toxicology/Pathology)

Webinar

Jun 23, 2022 | T14:00:00Z

Göttingen Minipigs in human relevant safety assessment - learnings from Roche (Safety Pharmacology and Toxicology/Pathology)

The selection of the non-rodent species is very important when performing toxicology and safety pharmacology studies. In this webinar, three experienced researchers from Roche - Susanne Mohr, Andrea Greiter-Wilke and Björn Jacobsen - will share their experiences, with a special focus on Göttingen Minipigs. The webinar includes a 40 min presentation followed by a Q&A session based on questions submitted “on-line” during the talk.

What’s good to know when considering Göttingen Minipigs for Juvenile toxicology studies?

Webinar

Jun 23, 2022 | T15:00:00Z

What’s good to know when considering Göttingen Minipigs for Juvenile toxicology studies?

Juvenile animal studies are increasingly being used to support the development of paediatric medicines. Göttingen Minipigs are ideal in many ways for such studies and are specifically mentioned in the close-to-final ICH S11 guideline. Edward Marsden, who has many years of experience in the field, will share his experiences regarding optimizing such studies which are often quite complex.

Vascular access and implantation of catheters in Göttingen Minipigs

Webinar

Jun 23, 2022 | T15:00:00Z

Vascular access and implantation of catheters in Göttingen Minipigs

Vascular access is key for successful studies and in this webinar, Adrian Zeltner will review the different options, including newer developments. Adrian has many years of experience in placing various catheters and in teaching in the techniques. The technical guide available and the options for ordering pre-implanted animals will also be briefly outlined.

Göttingen Minipigs in human relevant safety assessment - learnings from Roche (Safety Pharmacology and Toxicology/Pathology)

Webinar

Jun 23, 2022 |

Göttingen Minipigs in human relevant safety assessment - learnings from Roche (Safety Pharmacology and Toxicology/Pathology)

The selection of the non-rodent species is very important when performing toxicology and safety pharmacology studies. In this webinar, three experienced researchers from Roche - Susanne Mohr, Andrea Greiter-Wilke and Björn Jacobsen - will share their experiences, with a special focus on Göttingen Minipigs. The webinar includes a 40 min presentation followed by a Q&A session based on questions submitted “on-line” during the talk.

What’s good to know when considering Göttingen Minipigs for Juvenile toxicology studies?

Webinar

Jun 23, 2022 |

What’s good to know when considering Göttingen Minipigs for Juvenile toxicology studies?

Juvenile animal studies are increasingly being used to support the development of paediatric medicines. Göttingen Minipigs are ideal in many ways for such studies and are specifically mentioned in the close-to-final ICH S11 guideline. Edward Marsden, who has many years of experience in the field, will share his experiences regarding optimizing such studies which are often quite complex.

Vascular access and implantation of catheters in Göttingen Minipigs

Webinar

Jun 23, 2022 |

Vascular access and implantation of catheters in Göttingen Minipigs

Vascular access is key for successful studies and in this webinar, Adrian Zeltner will review the different options, including newer developments. Adrian has many years of experience in placing various catheters and in teaching in the techniques. The technical guide available and the options for ordering pre-implanted animals will also be briefly outlined.

Background Pathology in Göttingen Minipigs

Webinar

Jun 23, 2022 |

Background Pathology in Göttingen Minipigs

When performing toxicology studies, knowledge of the background pathology is extremely important and for Göttingen Minipigs much is known and has been published. Sean McKeag from Covance will present an overview, including what especially to be aware of, and give a status on the upcoming INHAND guidance document for standardized nomenclature. The 30 min webinar will end with a Q&A session based on questions submitted “on-line” during the talk.