We collect and share data about Göttingen Minipigs to support scientists in their research.
Whether you are new to Göttingen Minipigs in biomedical research or have years of experience working with them, you might find this page interesting. Use it to build your basics on histology and pathology or learn about fellow scientists' findings within specific areas of research. Explore the MR/CT imaging atlases of Göttingen Minipigs and their brain. Or use the reference work for vehicle systems and routes of administration to help build your study.
Download a selection of papers grouped into topics to illustrate areas in which Göttingen Minipigs have excelled.
The list of topics and papers is far from exhaustive but includes a selection of papers with a more general approach, which have contributed to the general understanding and characterisation of Göttingen Minipigs as a large animal model
Gain access to detailed CT/MRI scans of Göttingen Minipigs from both sexes and at different ages.
A comprehensive imaging atlas presenting detailed information about the physiology of Göttingen Minipigs has been made available for anyone interested in the anatomical evolution of Göttingen Minipigs.
A comprehensive selection of histological sections of the Göttingen Minipigs brain paired with MRI scans.
A comprehensive imaging atlas presenting detailed information about the physiology of Göttingen Minipigs has been made available for anyone interested in the anatomical evolution of Göttingen Minipigs.
A comprehensive selection of histological sections of the Göttingen Minipigs brain paired with MRI scans.
A comprehensive imaging atlas presenting detailed information about the physiology of Göttingen Minipigs has been made available for anyone interested in the anatomical evolution of Göttingen Minipigs.
This documentation enables a unique opportunity to follow the development of all organs over time and obtain new data.
The images are made from high-resolution CT- and MRI-scans and the atlas covers a wide range of information based on the scans. With these, a user-friendly virtual minipig can be created using freely available software, and organ development analyses can be performed.
Why the imaging atlas is important
The imaging atlas fully supports all three parametres of the 3R principles, which contribute with important steps in the development of safer and more effective medicines:
Replacement; as the access to and use of the imaging atlas can fully replace the use of new animals in similar studies
Reduction; as the use of the maging atlas can fully or partly reduce the number of animals used to obtain the same amount of scientific information
Refinement; as reducing animal distress is a direct result of a reduced need for operational studies, since knowledge can be obtained through the images, which also supports the definition of age and development-stage
Download this data sheet for instructions on how to gain access to the atlas.
A comprehensive selection of histological sections of the Göttingen Minipigs brain paired with MRI scans.
The atlas has been developed and made available by CENSE (Center for Experimental Neuroscience) at Aarhus University, Denmark. For more information about CENSE follow this link.
Learn about practical information on formulation and dosing in Göttingen Minipigs.
This meta article contains a broad catalog of used vehicles and excipients, indexing the findings and plenty of references for further investigation.
This meta article contains a broad catalog of used vehicles and excipients, indexing the findings and plenty of references for further investigation.
This meta article contains a broad catalog of used vehicles and excipients, indexing the findings and plenty of references for further investigation.
This study provides an in-depth analysis of the use of minipigs in drug development studies. The research focuses on the tolerability of various excipients in minipigs, aiming to reduce animal usage and optimize testing processes. The article contributes to the scientific community by sharing knowledge on excipient tolerability and compositions previously used in nonclinical studies, thereby preventing the testing of inadequate formulations. The findings of this research could potentially encourage scientists to consider the minipig as a viable alternative to other non-rodent species in drug development studies, given the known tolerability of a vehicle in the minipig.
A technical guide with the most basal dosing routes in Göttingen Minipigs incl. instructions in training and handling.
After an introduction to basic knowledge about Göttingen Minipigs as a species, this technical guide takes you through training and proper handling methods in a study set-up. This includes different restraining methods depending on the purpose. Following, the guide takes you through various dosing methods, blood sampling and vascular access.
A comprehensive study that has redefined the use of minipigs in regulatory toxicity testing, highlighting the minipig’s potential as a relevant model for safety testing.
The RETHINK project, is a comprehensive initiative aimed at evaluating the use of minipigs in regulatory toxicity testing. The project assembled expert study groups to review five different areas relating to the use of minipigs in regulatory safety testing. The findings suggested that there were no specific areas where restrictions to the use of minipigs in toxicology were required for welfare reasons. The minipig model was generally acceptable to regulatory authorities, provided it was adequately justified. The minipig was found to be an interesting model for safety testing due to numerous anatomical, physiological, genetic, and biochemical similarities to humans. In addition, many features of the minipig made it a practical and flexible model for safety testing.
Below are listed different parameters in Göttingen Minipigs that have been recorded in-house and in collaboration with experts.
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