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SCIENCE BASE
In our science base, we have collected links to a wide selection of relevant papers and knowledge-sharing. If you do not find what you are looking for, you are welcome to contact us.
Results (70)
Disease models
Anterograde Tracing From the Göttingen Minipig Motor and Prefrontal Cortex Displays a Topographic Subthalamic and Striatal Axonal Termination Pattern Comparable to Previous Findings in Primates
Johannes Bech Steinmüller, Carsten Reidies Bjarkam, Dariusz
Orlowski, et al. Nov 26, 2021
Orlowski, et al. Nov 26, 2021
Doi: 10.3389/fncir.2021.716145
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Disease models
Plant Recombinant Human Collagen Type I Hydrogels for Corneal Regeneration
Haagdorens, M., Edin, E., Fagerholm, P, et al.
Nov 1, 2021
Doi: 10.1007/s40883-021-00220-3
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Xenotransplantation
Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds
Sabrina Halecker, Julia Metzger, Christina Strube, et al.
Nov 8, 2021
Doi: 10.3390/microorganisms9122617
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Devices, Disease models, Safety pharmacology
A 3-D Finite-Element Minipig Model to Assess Brain Biomechanical Responses to Blast Exposure
Aravind Sundaramurthy, Vivek Bhaskar Kote, Noah Pearson, et
al. Nov 8, 2021
al. Nov 8, 2021
Doi: 10.3389/fbioe.2021.757755
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Devices
Low kV Computed Tomography of Parenchymal Abdominal Organs—A Systematic Animal Study of Different Contrast Media Injection Protocols
Daniel Overhoff, Gregor Jost, Michael McDermott et al.
Jul 12, 2021
Doi: 10.3390/tomography7040069
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Disease models
A systematic review of porcine models in translational pain research
Suzan Meijs, Martin Schmelz, Sigal Meilin, and Winnie Jensen
Nov 8, 2021
Doi: 10.1038/s41684-021-00862-4.
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Disease models
Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH
Laura Tvilling, Mark J. West, Andreas Glud, et al.
Oct 4, 2021
Doi: 10.1007/s00429-021-02337-1
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In vitro pharmacology
The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs
Søren Østergaard, Johan F. Paulsson, Jacob Kofoed, et al.
Oct 4, 2021
Doi: 10.1038/s41598-021-00654-3
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Disease models
Safety and efficacy of sFilm-FS, a novel biodegradable fibrin sealant, in Göttingen minipigs
Yuval Ramot, Michal Steiner, Yossi Lavie, et al.
Oct 13, 2021
Doi: 10.1293/tox.2021-0030
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Disease models
Unraveling the Metabolic Derangements Occurring in Noninfarcted Areas of Pig Hearts With Chronic Heart Failure
Cláudia Correia, Qing-Dong Wang, Gunilla Linhardt, et al.
Oct 13, 2021
Doi: 10.3389/fcvm.2021.753470
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Disease models, Safety pharmacology
[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction
Simon Bentsen, Andreas Clemmensen, Mathias Loft, et al.
Aug 5, 2021
Doi: 10.3390/diagnostics11101807
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Disease models, Safety pharmacology
Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases
Allan Valenzuela, Claire Tardiveau, Miriam Ayuso, et al.
Aug 5, 2021
Doi: 10.3390/13091442
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Disease models
Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome
Rittase WB, McCart EA, Muir JM, et al.
Aug 27, 2021
Doi: 10.1371/journal.pone.0256208
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Safety pharmacology, Toxicology
Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice
Namdari R, Jones K, Chuang SS, et al.
Nov 15, 2021
Doi: 10.1016/j.yrtph.2021.105029
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Guidelines, Toxicology
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig
Pardo ID, Manno RA, Capobianco R, et al.
Aug 16, 2021
Doi: 10.1177/01926233211019941
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Disease models, Genetically altered models
In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer’s Disease
Andersen OM, Bøgh N, Landau AM, et al.
Jul 13, 2021
Doi: 10.1101/2021.07.13.452149
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In vitro pharmacology, Toxicology
In Vitro and In Vivo Analysis of Ochratoxin A-Derived Glucuronides and Mercapturic Acids as Biomarkers of Exposure
Dekant R, Langer M, Lupp M, Chilaka CA, Mally A
Aug 23, 2021
Doi: 10.3390/toxins13080587
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Disease models
Investigating the Multi-Faceted Nature of Radiation-Induced Coagulopathies in a Göttingen Minipig Model of Hematopoietic Acute Radiation Syndrome
Hritzo B, Legesse B, Ward JM, et al.
Aug 16, 2021
Doi: 10.1667/RADE-20-00073.1.
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Disease models, In vitro pharmacology
Whole blood gene expression within days after total-body irradiation predicts long term survival in Gottingen minipigs
Chopra S, Moroni M, Sanjak J, et al.
Aug 5, 2021
Doi: 10.1038/s41598-021-95120-5
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Disease models, In vitro pharmacology
Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH
Tvilling L, West M, Glud AN, et al.
Sep 13, 2021
Doi: 10.1007/s00429-021-02337-1
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Disease models, Genetically altered models
The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues
Berthelsen MF, Riedel M, Cai H, et al.
Jun 16, 2021
Doi: 10.3390/cancers13123024
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Disease models, Toxicology
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration
Ding N, Yamamoto S, Chisaki I, Nakayama M, Matsumoto S, Hirabayashi H.
Jun 9, 2021
Doi: 10.1016/j.dmpk.2021.100408
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Disease models
Preclinical Development and Validation of ASP5354: A Near-Infrared Fluorescent Agent for Intraoperative Ureter Visualization
Fushiki H, Yoshikawa T, Matsuda T, Sato T, Suwa A
May 11, 2021
Doi: 10.1007/s11307-021-01613-0
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Disease models
Energy-Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and l-Menthol in Rat and Göttingen Minipig
Otake H, Yamaguchi M, Ogata F, et al.
May 12, 2021
Doi: 10.3390/ijms22105137
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Disease models
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Brenner GB, Giricz Z, Garamvölgyi R, et al.
Apr 17, 2021
Doi: 10.3791/61901
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Disease models
Obesity Development and Signs of Metabolic Abnormalities in Young Göttingen Minipigs Consuming Energy Dense Diets Varying in Carbohydrate Quality
Curtasu MV, Hedemann MS, Lærke HN, Knudsen KEB
May 6, 2021
Doi: 10.3390/nu13051560
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Disease models, Toxicology
Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs
Lumley L, Du F, Marrero-Rosado B, et al.
Apr 19, 2021
Doi: 10.1016/j.toxrep.2021.04.005
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Disease models
Hepatic blood flow in adult Göttingen minipigs and pre-pubertal Danish Landrace x Yorkshire pigs
Buyssens L, Clerck LD, Schelstraete W, et al.
Aug 16, 2021
Doi: 10.1177/00236772211000370
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Disease models, In vitro pharmacology, Toxicology
Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling
Buyssens L, Clerck LD, Schelstraete W, et al.
Apr 15, 2021
Doi: 10.3389/fphar.2021.665644
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Disease models, In vitro pharmacology
Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia
Armstrong AJ, Henke BR, Collado MS, et al.
Apr 13, 2021
Doi: 10.1021/acs.jmedchem.1c00124
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Disease models
Göttingen Minipigs as a Model to Evaluate Longevity, Functionality, and Memory of Immune Response Induced by Pertussis Vaccines
Vaure C, Grégoire-Barou V, Courtois V, Chautard E, Dégletagne C, Liu Y
Mar 17, 2021
Doi: 10.3389/fimmu.2021.613810
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Disease models, Genetically altered models
Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs
Maxeiner J, Sharma R, Amrhein C, et al.
Mar 29, 2021
Doi: 10.1016/j.vascn.2021.106956
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Devices, Safety pharmacology
An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention
Zaer H, Deshmukh A, Orlowski D, et al.
Feb 3, 2021
Doi: 10.3389/fnhum.2021.618626
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Disease models, Safety pharmacology
Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling
Hritzo B, Aghdam AY, Legesse B, et al.
Mar 23, 2021
Doi: 10.3390/ijms22063286
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Genetically altered models
The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues
Berthelsen et al.
Jun 16, 2021
Doi: 10.3390/cancers13123024
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Disease models, In vitro pharmacology, Safety pharmacology, Toxicology
The Porcine Immune System and the Toolbox Available to Study it
Ellegaard Göttingen Minipigs A/S
Dec 16, 2019
The pig has a long-standing role in vaccine development and as model for human infectious diseases, and the immune system in the pig is well characterized.
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Safety pharmacology, Toxicology
Göttingen Minipigs in ADME studies – specific advantages
Ellegaard Göttingen Minipigs A/S
Dec 17, 2019
For several routes of administration, Göttingen Minipigs have specific advantages over other preclinical species in terms of predicting the drug absorption in humans…
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Safety pharmacology
Rapid One-Step Generation of Genetically Modified Göttingen Minipigs for Human Disease Modelling
Genome Biologics, Charles River Laboratories Copenhagen A/S, Ellegaard Göttingen Minipigs A/S
Mar 2, 2020
For decades Göttingen Minipigs has been used in biomedical research, with their many anatomical, physiological and pathophysiological similarities to humans, and as…
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Toxicology
The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations
Forster et al.
Dec 1, 2010
Doi: 10.1016/j.vascn.2010.05.008
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Toxicology
The minipig as a platform for new technologies in toxicology
Forster et al.
Dec 1, 2010
Doi: 10.1016/j.vascn.2010.05.007
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Guidelines
Genetic management of the Göttingen Minipig population
Simianer et al.
Dec 1, 2010
Doi: 10.1016/j.vascn.2010.05.004
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Toxicology
The utility of the minipig as an animal model in regulatory toxicology
Bode et al.
Dec 1, 2010
Doi: 10.1016/j.vascn.2010.05.009
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Devices, Safety pharmacology, Toxicology
Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products
Van der Laan et al.
Dec 1, 2010
Doi: 10.1016/j.vascn.2010.05.005
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Animal welfare
Welfare of the minipig with special reference to use in regulatory toxicology studies
Ellegaard et al.
Dec 1, 2010
Doi: 10.1016/j.vascn.2010.05.006
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Animal welfare, Toxicology
Ethical implications of using the minipig in regulatory toxicology studies
Webster et al.
Dec 1, 2010
Doi: 10.1016/j.vascn.2010.05.002
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Toxicology
The RETHINK project: Minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment
Forster et al.
Dec 1, 2010
Doi: 10.1016/j.vascn.2010.05.003
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