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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models

Heart Failure With Preserved Ejection Fraction: Heterogeneous Syndrome, Diverse Preclinical Models

Jason Roh, Joseph A. Hill, Abhilasha Singh, et al. Jun 9, 2022

Doi: 10.1161/CIRCRESAHA.122.320257

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Genetically altered models

Epigenetic regulation of BAF60A determines efficiency of miniature swine iPSC generation

Hongli Jiao, Ming-Song Lee, Athillesh Sivapatham, et al. Jun 17, 2022

Doi: 10.1038/s41598-022-12919-6
 

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models

FSHD Therapeutic Strategies: What Will It Take to Get to Clinic?

Charis L. Himeda and Peter L. Jones. May 25, 2022

Doi: 10.3390/jpm12060865

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models

Spontaneous partial recovery of striatal dopaminergic uptake despite nigral cell loss in asymptomatic MPTP-lesioned female minipigs

Thea P. Lillethorup, Ove Noer, Aage Kristian Olsen Alstrup, et al. Jul 11, 2022

Doi: 10.1016/j.neuro.2022.05.006

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models, Safety pharmacology

Characterization and Pharmacological Validation of a Preclinical Model of NASH in Göttingen Minipigs

Valérie Duvivier, Stéphanie Creusot, Olivier Broux, et al.
Apr 12, 2022

Doi: 10.1016/j.jceh.2021.09.001

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models, In vitro pharmacology

Whole blood gene expression within days after total‑body irradiation predicts long term survival inGottingen minipigs

Sunita Chopra, Maria Moroni, Jaleal Sanjak, et al.

Doi: 10.1038/s41598-021-95120-5

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models, Safety pharmacology

No sex-related differences in infarct size, no-reflow and protection by ischaemic preconditioning in Göttingen Minipigs

Petra Kleinbongard, Helmut Lieder, Andreas Skyschally, et al. Apr 15, 2022

Doi: 10.1093/cvr/cvac062

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

In vitro pharmacology, Xenotransplantation

Decellularized Organ-Derived Scaffold Is a Promising Carrier for Human Induced Pluripotent Stem Cells-Derived Hepatocytes

Hideaki Kojima, Hiroshi Yagi, Hiroko Kushige, et al. Apr 7, 2022

Doi: 10.3390/cells11081258

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Devices, Disease models

Assessment of Two Commonly used Dermal Regeneration Templates in a Swine Model without Skin Grafting

Wiebke Eisler, Jan-Ole Baur, Manuel Held, et al. Feb 9, 2022

Doi: 10.3390/app12063205

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Devices, Disease models, Safety pharmacology

Implantation of telemetric blood pressure transmitters in Göttingen Minipigs: Validation of 24-h systemic blood pressure and heart rate monitoring and influence of anaesthesia

Michelle Fischer Carlsen, Berit Østergaard Christoffersen, Rikke Lindgaard, et al. May 9, 2022

Doi: 10.1016/j.vascn.2022.107168

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models

Experimental model of portal hypertension and esophagogastric varices in minipigs: pressure and endoscopic pilot study

Fauze Maluf-Filho, Alberto Meyer, Pierre Pirchner, et al. Mar 7, 2022

Doi: 10.1590/acb370103

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Xenotransplantation

Rare isolation of human-tropic recombinant porcine endogenous retroviruses PERV-A/C from Göttingen Minipigs

Sabrina Halecker, Ludwig Krabben, Yannick Kristiansen, et al. Feb 21, 2022

Doi: 10.1186/s12985-022-01742-0

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Devices

The minipig intraoral dental implant model: A systematic review and meta-analysis

Marta Liliana Musskopf, Amanda Finger Stadler, Ulf ME Wikesjö, et al. Feb 28, 2022

Doi: 10.1371/ journal.pone.0264475

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Devices, Disease models

Mechanoporation enables rapid and efficient radiolabeling of stem cells for PET imaging

Kyung Oh Jung, Ashok Joseph Theruvath, Hossein Nejadnik, et al. Feb 22, 2022

Doi: 10.1038/s41598-022-06938-6

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models

Investigating the effect of obesity on adipose-derived stem cells (ASCs) using Göttingen Minipigs

Maria Meyhoff-Madsen, Esben Østrup, Merete Fredholm, and Susanna Cirera. Feb 12, 2022

Doi: 10.1101/2022.02.11.477943

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models

A Strain Rate-Dependent Constitutive Model for Göttingen Minipig Cerebral Arteries

Noah Pearson, Gregory M Boiczyk, Vivek Bhaskar Kote, et al. Aug 1, 2022

Doi: 10.1115/1.4053796
 

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models, Safety pharmacology, Toxicology

Characterization of a novel non-steroidal glucocorticoid receptor agonist optimized for topical treatment

Stefan Eirefelt, Martin Stahlhut, Naila Svitacheva, et al. Jan 27, 2022

Doi: 10.1038/s41598-022-05471

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Guidelines

Taking good care of Göttingen Minipigs

Adrian Zeltner, Ellegaard Göttingen Minipigs A/S

When receiving Göttingen Minipigs, it is important to remember the following:

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Science base

Disease models

Anterograde Tracing From the Göttingen Minipig Motor and Prefrontal Cortex Displays a Topographic Subthalamic and Striatal Axonal Termination Pattern Comparable to Previous Findings in Primates

Johannes Bech Steinmüller, Carsten Reidies Bjarkam, Dariusz
Orlowski, et al.
Nov 26, 2021

Doi: 10.3389/fncir.2021.716145

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Science base

Disease models

Plant Recombinant Human Collagen Type I Hydrogels for Corneal Regeneration

Haagdorens, M., Edin, E., Fagerholm, P, et al. Nov 1, 2021

Doi: 10.1007/s40883-021-00220-3

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Science base

Xenotransplantation

Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds

Sabrina Halecker, Julia Metzger, Christina Strube, et al. Nov 8, 2021

Doi: 10.3390/microorganisms9122617

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Science base

Devices, Disease models, Safety pharmacology

A 3-D Finite-Element Minipig Model to Assess Brain Biomechanical Responses to Blast Exposure

Aravind Sundaramurthy, Vivek Bhaskar Kote, Noah Pearson, et
al.
Nov 8, 2021

Doi: 10.3389/fbioe.2021.757755

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Science base

Devices

Low kV Computed Tomography of Parenchymal Abdominal Organs—A Systematic Animal Study of Different Contrast Media Injection Protocols

Daniel Overhoff, Gregor Jost, Michael McDermott et al. Jul 12, 2021

Doi: 10.3390/tomography7040069

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Science base

Disease models

A systematic review of porcine models in translational pain research

Suzan Meijs, Martin Schmelz, Sigal Meilin, and Winnie Jensen Nov 8, 2021

Doi: 10.1038/s41684-021-00862-4.

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Science base

Disease models

Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH

Laura Tvilling, Mark J. West, Andreas Glud, et al. Oct 4, 2021

Doi: 10.1007/s00429-021-02337-1

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Science base

In vitro pharmacology

The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs

Søren Østergaard, Johan F. Paulsson, Jacob Kofoed, et al. Oct 4, 2021

Doi: 10.1038/s41598-021-00654-3

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Science base

Disease models

Safety and efficacy of sFilm-FS, a novel biodegradable fibrin sealant, in Göttingen minipigs

Yuval Ramot, Michal Steiner, Yossi Lavie, et al. Oct 13, 2021

Doi: 10.1293/tox.2021-0030

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Science base

Disease models

Unraveling the Metabolic Derangements Occurring in Noninfarcted Areas of Pig Hearts With Chronic Heart Failure

Cláudia Correia, Qing-Dong Wang, Gunilla Linhardt, et al. Oct 13, 2021

Doi: 10.3389/fcvm.2021.753470

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Science base

Disease models, Safety pharmacology

[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction

Simon Bentsen, Andreas Clemmensen, Mathias Loft, et al. Aug 5, 2021

Doi: 10.3390/diagnostics11101807

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Science base

Disease models, Safety pharmacology

Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases

Allan Valenzuela, Claire Tardiveau, Miriam Ayuso, et al. Aug 5, 2021

Doi: 10.3390/13091442

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Science base

Guidelines

Anaesthesia & Analgesia Göttingen Minipigs

Adrian Zeltner Feb 8, 2022

Ellegaard Göttingen Minipigs can easily be anaesthetised for several hours without a higher risk of complications.

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Animal welfare

Taking Blood from Göttingen Minipigs while placed in a sling

Ellegaard Göttingen Minipigs A/S Nov 25, 2021

Minipigs, Iike any other animal. do not particularly like to be re­strained and being turned on their back with their belly exposed.

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Science base

Disease models

Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome

Rittase WB, McCart EA, Muir JM, et al. Aug 27, 2021

Doi: 10.1371/journal.pone.0256208

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Science base

Safety pharmacology, Toxicology

Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice

Namdari R, Jones K, Chuang SS, et al. Nov 15, 2021

Doi: 10.1016/j.yrtph.2021.105029

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Science base

Guidelines, Toxicology

Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig

Pardo ID, Manno RA, Capobianco R, et al. Aug 16, 2021

Doi: 10.1177/01926233211019941

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Science base

Disease models, Genetically altered models

In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer’s Disease

Andersen OM, Bøgh N, Landau AM, et al. Jul 13, 2021

Doi: 10.1101/2021.07.13.452149

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Science base

In vitro pharmacology, Toxicology

In Vitro and In Vivo Analysis of Ochratoxin A-Derived Glucuronides and Mercapturic Acids as Biomarkers of Exposure

Dekant R, Langer M, Lupp M, Chilaka CA, Mally A Aug 23, 2021

Doi: 10.3390/toxins13080587

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Science base

Disease models

Investigating the Multi-Faceted Nature of Radiation-Induced Coagulopathies in a Göttingen Minipig Model of Hematopoietic Acute Radiation Syndrome

Hritzo B, Legesse B, Ward JM, et al. Aug 16, 2021

Doi: 10.1667/RADE-20-00073.1.

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Science base

Disease models, In vitro pharmacology

Whole blood gene expression within days after total-body irradiation predicts long term survival in Gottingen minipigs

Chopra S, Moroni M, Sanjak J, et al. Aug 5, 2021

Doi: 10.1038/s41598-021-95120-5

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Science base

Disease models, In vitro pharmacology

Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH

Tvilling L, West M, Glud AN, et al. Sep 13, 2021

Doi: 10.1007/s00429-021-02337-1

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Science base

Disease models, Genetically altered models

The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues

Berthelsen MF, Riedel M, Cai H, et al. Jun 16, 2021

Doi: 10.3390/cancers13123024

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Science base

Disease models, Toxicology

Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration

Ding N, Yamamoto S, Chisaki I, Nakayama M, Matsumoto S, Hirabayashi H. Jun 9, 2021

Doi: 10.1016/j.dmpk.2021.100408

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Science base

Disease models

Preclinical Development and Validation of ASP5354: A Near-Infrared Fluorescent Agent for Intraoperative Ureter Visualization

Fushiki H, Yoshikawa T, Matsuda T, Sato T, Suwa A May 11, 2021

Doi: 10.1007/s11307-021-01613-0

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Science base

Disease models

Energy-Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and l-Menthol in Rat and Göttingen Minipig

Otake H, Yamaguchi M, Ogata F, et al. May 12, 2021

Doi: 10.3390/ijms22105137

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Science base

Disease models

Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs

Brenner GB, Giricz Z, Garamvölgyi R, et al. Apr 17, 2021

Doi: 10.3791/61901

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Science base

Disease models

Obesity Development and Signs of Metabolic Abnormalities in Young Göttingen Minipigs Consuming Energy Dense Diets Varying in Carbohydrate Quality

Curtasu MV, Hedemann MS, Lærke HN, Knudsen KEB May 6, 2021

Doi: 10.3390/nu13051560

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Science base

Disease models, Toxicology

Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs

Lumley L, Du F, Marrero-Rosado B, et al. Apr 19, 2021

Doi: 10.1016/j.toxrep.2021.04.005

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Science base

Disease models

Hepatic blood flow in adult Göttingen minipigs and pre-pubertal Danish Landrace x Yorkshire pigs

Buyssens L, Clerck LD, Schelstraete W, et al. Aug 16, 2021

Doi: 10.1177/00236772211000370

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Science base

Disease models, In vitro pharmacology, Toxicology

Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling

Buyssens L, Clerck LD, Schelstraete W, et al. Apr 15, 2021

Doi: 10.3389/fphar.2021.665644

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Science base

Disease models, In vitro pharmacology

Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia

Armstrong AJ, Henke BR, Collado MS, et al. Apr 13, 2021

Doi: 10.1021/acs.jmedchem.1c00124

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Science base

Disease models

Göttingen Minipigs as a Model to Evaluate Longevity, Functionality, and Memory of Immune Response Induced by Pertussis Vaccines

Vaure C, Grégoire-Barou V, Courtois V, Chautard E, Dégletagne C, Liu Y Mar 17, 2021

Doi: 10.3389/fimmu.2021.613810

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Science base

Disease models, Genetically altered models

Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs

Maxeiner J, Sharma R, Amrhein C, et al. Mar 29, 2021

Doi: 10.1016/j.vascn.2021.106956

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Science base

Devices, Safety pharmacology

An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention

Zaer H, Deshmukh A, Orlowski D, et al. Feb 3, 2021

Doi: 10.3389/fnhum.2021.618626

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Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Disease models, Safety pharmacology

Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling

Hritzo B, Aghdam AY, Legesse B, et al. Mar 23, 2021

Doi: 10.3390/ijms22063286

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Science base

Genetically altered models

The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues

Berthelsen et al. Jun 16, 2021

Doi: 10.3390/cancers13123024

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Science base

Disease models, In vitro pharmacology, Safety pharmacology, Toxicology

The Porcine Immune System and the Toolbox Available to Study it

Ellegaard Göttingen Minipigs A/S Dec 16, 2019

The pig has a long-standing role in vaccine development and as model for human infectious diseases, and the immune system in the pig is well characterized.