
Results (70)

Disease models
Anterograde Tracing From the Göttingen Minipig Motor and Prefrontal Cortex Displays a Topographic Subthalamic and Striatal Axonal Termination Pattern Comparable to Previous Findings in Primates
Orlowski, et al. Nov 26, 2021
Doi: 10.3389/fncir.2021.716145

Disease models
Plant Recombinant Human Collagen Type I Hydrogels for Corneal Regeneration
Doi: 10.1007/s40883-021-00220-3

Xenotransplantation
Virological and Parasitological Characterization of Mini-LEWE Minipigs Using Improved Screening Methods and an Overview of Data on Various Minipig Breeds
Doi: 10.3390/microorganisms9122617

Devices, Disease models, Safety pharmacology
A 3-D Finite-Element Minipig Model to Assess Brain Biomechanical Responses to Blast Exposure
al. Nov 8, 2021
Doi: 10.3389/fbioe.2021.757755

Devices
Low kV Computed Tomography of Parenchymal Abdominal Organs—A Systematic Animal Study of Different Contrast Media Injection Protocols
Doi: 10.3390/tomography7040069

Disease models
A systematic review of porcine models in translational pain research
Doi: 10.1038/s41684-021-00862-4.

Disease models
Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH
Doi: 10.1007/s00429-021-02337-1

In vitro pharmacology
The effect of fatty diacid acylation of human PYY3-36 on Y2 receptor potency and half-life in minipigs
Doi: 10.1038/s41598-021-00654-3

Disease models
Safety and efficacy of sFilm-FS, a novel biodegradable fibrin sealant, in Göttingen minipigs
Doi: 10.1293/tox.2021-0030

Disease models
Unraveling the Metabolic Derangements Occurring in Noninfarcted Areas of Pig Hearts With Chronic Heart Failure
Doi: 10.3389/fcvm.2021.753470

Disease models, Safety pharmacology
[68Ga]Ga-NODAGA-E[(cRGDyK)]2 Angiogenesis PET/MR in a Porcine Model of Chronic Myocardial Infarction
Doi: 10.3390/diagnostics11101807

Disease models, Safety pharmacology
Safety Testing of an Antisense Oligonucleotide Intended for Pediatric Indications in the Juvenile Göttingen Minipig, including an Evaluation of the Ontogeny of Key Nucleases
Doi: 10.3390/13091442



Disease models
Effects of captopril against radiation injuries in the Göttingen minipig model of hematopoietic-acute radiation syndrome
Doi: 10.1371/journal.pone.0256208

Safety pharmacology, Toxicology
Species selection for nonclinical safety assessment of drug candidates: Examples of current industry practice
Doi: 10.1016/j.yrtph.2021.105029

Guidelines, Toxicology
Nervous System Sampling for General Toxicity and Neurotoxicity Studies in the Laboratory Minipig With Emphasis on the Göttingen Minipig
Doi: 10.1177/01926233211019941

Disease models, Genetically altered models
In vivo evidence that SORL1, encoding the endosomal recycling receptor SORLA, can function as a causal gene in Alzheimer’s Disease
Doi: 10.1101/2021.07.13.452149

In vitro pharmacology, Toxicology
In Vitro and In Vivo Analysis of Ochratoxin A-Derived Glucuronides and Mercapturic Acids as Biomarkers of Exposure
Doi: 10.3390/toxins13080587

Disease models
Investigating the Multi-Faceted Nature of Radiation-Induced Coagulopathies in a Göttingen Minipig Model of Hematopoietic Acute Radiation Syndrome
Doi: 10.1667/RADE-20-00073.1.

Disease models, In vitro pharmacology
Whole blood gene expression within days after total-body irradiation predicts long term survival in Gottingen minipigs
Doi: 10.1038/s41598-021-95120-5

Disease models, In vitro pharmacology
Anatomy and histology of the Göttingen minipig adenohypophysis with special emphasis on the polypeptide hormones: GH, PRL, and ACTH
Doi: 10.1007/s00429-021-02337-1

Disease models, Genetically altered models
The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues
Doi: 10.3390/cancers13123024

Disease models, Toxicology
Utility of Göttingen minipigs for the prediction of human pharmacokinetic profiles after intravenous drug administration
Doi: 10.1016/j.dmpk.2021.100408

Disease models
Preclinical Development and Validation of ASP5354: A Near-Infrared Fluorescent Agent for Intraoperative Ureter Visualization
Doi: 10.1007/s11307-021-01613-0

Disease models
Energy-Dependent Endocytosis Is Responsible for Skin Penetration of Formulations Based on a Combination of Indomethacin Nanoparticles and l-Menthol in Rat and Göttingen Minipig
Doi: 10.3390/ijms22105137

Disease models
Post-Myocardial Infarction Heart Failure in Closed-chest Coronary Occlusion/Reperfusion Model in Göttingen Minipigs and Landrace Pigs
Doi: 10.3791/61901

Disease models
Obesity Development and Signs of Metabolic Abnormalities in Young Göttingen Minipigs Consuming Energy Dense Diets Varying in Carbohydrate Quality
Doi: 10.3390/nu13051560

Disease models, Toxicology
Soman-induced toxicity, cholinesterase inhibition and neuropathology in adult male Göttingen minipigs
Doi: 10.1016/j.toxrep.2021.04.005

Disease models
Hepatic blood flow in adult Göttingen minipigs and pre-pubertal Danish Landrace x Yorkshire pigs
Doi: 10.1177/00236772211000370

Disease models, In vitro pharmacology, Toxicology
Hepatic Cytochrome P450 Abundance and Activity in the Developing and Adult Göttingen Minipig: Pivotal Data for PBPK Modeling
Doi: 10.3389/fphar.2021.665644

Disease models, In vitro pharmacology
Identification of 2,2-Dimethylbutanoic Acid (HST5040), a Clinical Development Candidate for the Treatment of Propionic Acidemia and Methylmalonic Acidemia
Doi: 10.1021/acs.jmedchem.1c00124

Disease models
Göttingen Minipigs as a Model to Evaluate Longevity, Functionality, and Memory of Immune Response Induced by Pertussis Vaccines
Doi: 10.3389/fimmu.2021.613810

Disease models, Genetically altered models
Genomics Integrated Systems Transgenesis (GENISYST) for gain-of-function disease modelling in Göttingen Minipigs
Doi: 10.1016/j.vascn.2021.106956

Devices, Safety pharmacology
An Intracortical Implantable Brain-Computer Interface for Telemetric Real-Time Recording and Manipulation of Neuronal Circuits for Closed-Loop Intervention
Doi: 10.3389/fnhum.2021.618626

Disease models, Safety pharmacology
Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling
Doi: 10.3390/ijms22063286

Genetically altered models
The CRISPR/Cas9 Minipig—A Transgenic Minipig to Produce Specific Mutations in Designated Tissues
Doi: 10.3390/cancers13123024

Disease models, In vitro pharmacology, Safety pharmacology, Toxicology
The Porcine Immune System and the Toolbox Available to Study it
The pig has a long-standing role in vaccine development and as model for human infectious diseases, and the immune system in the pig is well characterized.


Safety pharmacology, Toxicology
Göttingen Minipigs in ADME studies – specific advantages
For several routes of administration, Göttingen Minipigs have specific advantages over other preclinical species in terms of predicting the drug absorption in humans…

Safety pharmacology
Rapid One-Step Generation of Genetically Modified Göttingen Minipigs for Human Disease Modelling
For decades Göttingen Minipigs has been used in biomedical research, with their many anatomical, physiological and pathophysiological similarities to humans, and as…



Toxicology
The RETHINK project on minipigs in the toxicity testing of new medicines and chemicals: Conclusions and recommendations
Doi: 10.1016/j.vascn.2010.05.008

Toxicology
The minipig as a platform for new technologies in toxicology
Doi: 10.1016/j.vascn.2010.05.007

Guidelines
Genetic management of the Göttingen Minipig population
Doi: 10.1016/j.vascn.2010.05.004

Toxicology
The utility of the minipig as an animal model in regulatory toxicology
Doi: 10.1016/j.vascn.2010.05.009

Devices, Safety pharmacology, Toxicology
Regulatory acceptability of the minipig in the development of pharmaceuticals, chemicals and other products
Doi: 10.1016/j.vascn.2010.05.005

Animal welfare
Welfare of the minipig with special reference to use in regulatory toxicology studies
Doi: 10.1016/j.vascn.2010.05.006

Animal welfare, Toxicology
Ethical implications of using the minipig in regulatory toxicology studies
Doi: 10.1016/j.vascn.2010.05.002

Toxicology
The RETHINK project: Minipigs as models for the toxicity testing of new medicines and chemicals: an impact assessment
Doi: 10.1016/j.vascn.2010.05.003



