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![Late Health Effects of Partial Body Irradiation Injury in a Minipig Model Are Associated with Changes in Systemic and Cardiac IGF-1 Signaling](/sites/default/files/styles/large/public/2021-10/Science-base_paper-img.jpg.webp?itok=mZCQLopf)
Genetically altered models
Genetically altered Göttingen Minipigs, carrying a mini repertoire of human Ig-γ1/γ4 heavy and the human κ light chain genes, show tolerance to a broad range of human antibodies. This provides a novel model for safety testing and an important and viable alternative for toxicology studies of therapeutic antibodies in non-human primates.
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